APHAMAX® ATTENUATES INFLAMMATORY AND OXIDATIVE STRESS IN 2, 4-DINITROBENZENE SULFONIC ACID-INDUCED COLITIS IN RAT AMELIORATING INTESTINAL FUNCTIONALITY

Accumulating evidences indicate that inflammatory and oxidative stress play an essential role in the pathogenesis and progression of inflammatory bowel disease (IBD). In IBD the excessive production of reactive oxygen species (ROS) and nitrogen metabolites contribute to tissue injury and could have also a profound impact on gut functions, including motility. We characterised the inflammatory and oxidative condition and the impact on colon motility in an experimental rat model of colitis, the 2, 4-dinitrobenzene sulfonic acid (DNBS)- induced colitis, and we evaluated if oral treatment with a nat- ural extract of Aphanizomenon flos-aquae (AFA) AphaMax®, containing concentrated quantity of AFA…