Bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma

Purpose: To review the main clinical-radiographic, therapeutic, and preventive aspects of osteonecrosis related to intravenous bisphosphonate therapy in patients with multiple myeloma. Materials and methods: Between 2005 and 2006, we studied four patients with previous diagnosis of multiple myeloma treated with intravenous zoledronic acid, presenting nonhealing extraction sockets and intraoral exposed bone. We assessed the location of lesions, the relation with previous history of dento-alveolar surgery procedures, the clinical features, the treatments carried out, and the outcomes achieved. Results: All the patients were treated with chlorhexidine mouthwashes and oral amoxycilin-clavulanic…