0000000001270815

AUTHOR

C Pohl

showing 2 related works from this author

Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient …

2001

Abstract Recombinant immunoreceptors with specificity for the carcinoembryonic Ag (CEA) can redirect grafted T cells to a MHC/Ag-independent antitumor response. To analyze receptor-mediated cellular activation in the context of CD28 costimulation, we generated: 1) CEA+ colorectal tumor cells that express simultaneously B7-1 and B7-2, and 2) CEA-specific immunoreceptors that harbor intracellularly the signaling moities either of CD28 (BW431/26-scFv-Fc-CD28), CD3ζ (BW431/26-scFv-Fc-CD3ζ), or FcεRIγ (BW431/26-scFv-Fc-γ). By retroviral gene transfer, we grafted activated T cells from the peripheral blood with these immunoreceptors. T cells that express the FcεRIγ or CD3ζ signaling receptor lyse…

CD4-Positive T-LymphocytesCD3 ComplexT cellCD3T-LymphocytesImmunologyEpitopes T-Lymphocytechemical and pharmacologic phenomenaBiologyCD8-Positive T-LymphocytesMajor histocompatibility complexLymphocyte ActivationTransfectionEpitopeAntigenCD28 AntigensAntigens NeoplasmmedicineTumor Cells CulturedImmunology and AllergyHumansReceptors ImmunologicReceptorReceptors IgGCD28hemic and immune systemsMolecular biologyCoculture TechniquesRecombinant ProteinsCell biologyCarcinoembryonic Antigenmedicine.anatomical_structurebiology.proteinB7-1 AntigenInterleukin-2CD8Signal TransductionJournal of immunology (Baltimore, Md. : 1950)
researchProduct

Physical inactivity in patients with rheumatoid arthritis: data from twenty-one countries in a cross-sectional, international study.

2008

Objective Regular physical activity is associated with decreased morbidity and mortality. Traditionally, patients with rheumatoid arthritis (RA) have been advised to limit physical exercise. We studied the prevalence of physical activity and associations with demographic and disease-related variables in patients with RA from 21 countries. Methods The Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis (QUEST-RA) is a cross-sectional study that includes a self-report questionnaire and clinical assessment of nonselected consecutive outpatients with RA who are receiving usual clinical care. Frequency of physical exercise (≥30 minutes with at least some shortness of brea…

QuestionnairesMalemedicine.medical_specialtyInternationalityCross-sectional studyImmunologyArthritisPhysical exerciseMotor Activity*Arthritis Rheumatoid/physiopathologyArthritis RheumatoidRheumatologyInternal medicineImmunopathologySurveys and QuestionnairesmedicineImmunology and AllergyHumansPharmacology (medical)In patient*Motor Activitybusiness.industryMiddle Agedmedicine.diseaseComorbidityObesityCross-Sectional StudiesRheumatoid arthritisPhysical therapyFemalebusiness
researchProduct