0000000001274731
AUTHOR
A Martorana
showing 13 related works from this author
Efficacy of Rapamycin as Inducer of Hb F in Primary Erythroid Cultures from Sickle Cell Disease and β-Thalassemia Patients.
2015
Phenotypic improvement of hemoglobinopathies such as sickle cell disease and β-thalassemia (β-thal) has been shown in patients with high levels of Hb F. Among the drugs proposed to increase Hb F production, hydroxyurea (HU) is currently the only one proven to improve the clinical course of these diseases. However, Hb F increase and patient's response are highly variable, indicating that new pharmacological agents could be useful for patients not responding to HU or showing a reduction of response during long-term therapy. In this study we evaluated the efficacy of rapamycin, a lypophilic macrolide used for the prevention of acute rejection in renal transplant recipients, as an inducer of Hb…
SYNTHESIS OF 3-(2-PHENYL-1,3-THIAZOL-4-YL)-1H-INDOLES, NEW DERIVATIVES WITH POTENTIAL ANTINEOPLASTIC ACTIVITY
2008
SYNTHESIS OF PYRROLO[3,4-H]QUINAZOLIN-2-ONE A NEW RING SYSTEM WITH POTENTIAL PHOTOTHERAPEUTIC ACTIVITY
2007
SINTESI DI 2,5-BIS[3-(7-AZAINDOLIL)]TIOFENI ANALOGHI DELLA NORTOPSENTINA
2007
P16 ink4A, p53 alterations and S phase fraction are predictive of clinical outcome in laryngeal squamous cell carcinoma.
2006
4-AZA E 7-AZA-ISOINDOLO[1,2-a]CHINOSSALINE: DUE NUOVI SISTEMI ETEROCICLICI A POTENZIALE ATTIVITÀ ANTITUMORALE
2007
Sintesi ed Attività Antitumorale di Bis(indolil)eterocicli: Analoghi dell’Alcaloide Marino Nortopsentina
2006
NO reduction on Pt(1%)/ Ce0.6Zr0.4O2 catalyst: effect of Strong Metal Support Interaction (SMSI) on the catalytic activity
2004
Expression of a specific Thymidylate synthase polimorfic allele in metastatic colorectal patients is regulated by Myeloid Zinc Finger 1.
2013
Thymidylate Synthase (TS) is the target enzyme for fluoropyrimidine anticancer drugs. Its expression is regulated by the number of functional upstream stimulatory factor (USF) E box consensus elements present on its 5’ untranslated region. To date are known different polymorphisms, the first one consisting of 2 or 3 repeat of a 28 bp sequence, a further single nucleotide polymorphism (SNP) consisting in a G>C substitution within the second repeat of 3R (3RG>3RC) and recently it has been identified an additional SNP a G>C substitution at the 12th nucleotide in the first repeat of the 2R allele (2RG>2RC). These polymorphisms can influence TS expression, in particular 3R/3R genotype and the pr…
SINTESI DELL'ISONETROPSINA E DELL'ISOMERO DIMERICO DELLA DISTAMICIA A
2006
Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia
2020
Objectives Few studies have analyzed factors associated with delirium subtypes. In this study, we investigate factors associated with subtypes of delirium only in patients with dementia to provide insights on the possible prevention and treatments. Design This is a cross-sectional study nested in the "Delirium Day" study, a nationwide Italian point-prevalence study. Setting and participants Older patients admitted to 205 acute and 92 rehabilitation hospital wards. Measures Delirium was evaluated with the 4-AT and the motor subtypes with the Delirium Motor Subtype Scale. Dementia was defined by the presence of a documented diagnosis in the medical records and/or prescription of acetylcholine…