Author: Barbara Feigk

0000000001277754

AUTHOR

Barbara Feigk

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Differential changes in purine nucleotides after Doxorubicin treatment of human cancer cells in vitro

2002

The present investigation was performed to elucidate the role of purine nucleotides as potential indicators of chemosensitivity of malignant tumors. Drug-sensitive (s) and -resistant (r) tumor cell lines grown as monolayers (s: T47D, MCF-7 wild-type; r: NCI/ADR-RES, MCF-7/MDR) or as multicellular spheroids (T47D; NCI/ADR-RES) were exposed to 0.1, 1.0, and 10.0 microM Doxorubicin for up to 24 h. Purine nucleotides were assayed using HPLC and with some selected spheroids using imaging bioluminescence. The data show that in the time frame of the experiments reproducible and statistically significant changes in the nucleotides only occur at the highest drug concentration investigated. Under the…

PurineCancer ResearchOligomycinGTP'Antineoplastic AgentsIn Vitro TechniquesBiologychemistry.chemical_compoundAdenosine TriphosphateIn vivoSpheroids CellularTumor Cells CulturedmedicineHumansNucleotideDoxorubicinATP Binding Cassette Transporter Subfamily B Member 1Chromatography High Pressure Liquidchemistry.chemical_classificationBiological activityMolecular biologyDrug Resistance MultipleIn vitroOncologyBiochemistrychemistryDoxorubicinDrug Resistance NeoplasmLuminescent MeasurementsGuanosine Triphosphatemedicine.drugInternational Journal of Oncology

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