0000000001277900

AUTHOR

Randall Espinoza

showing 1 related works from this author

Neurochemical correlates of rapid treatment response to electroconvulsive therapy in patients with major depression

2016

Background: Electroconvulsive therapy (ECT) is a highly effective brain stimulation treatment for severe depression. Identifying neurochemical changes linked with ECT may point to biomarkers and predictors of successful treatment response. Methods: We used proton magnetic resonance spectroscopy (1H-MRS) to measure longitudinal changes in glutamate/glutamine (Glx), creatine (Cre), choline (Cho) and N-acetylaspartate (NAA) in the dorsal (dACC) and subgenual anterior cingulate cortex (sgACC) and bilateral hippocampus in patients receiving ECT scanned at baseline, after the second ECT session and after the ECT treatment series. Patients were compared with demographically similar controls at bas…

MaleBipolar Disordermedicine.medical_treatmentProton Magnetic Resonance SpectroscopyHippocampusHippocampuschemistry.chemical_compound0302 clinical medicineElectroconvulsive therapyMedicineCholinePharmacology (medical)Longitudinal StudiesElectroconvulsive TherapyDepression (differential diagnoses)PsychiatryDepressionPsychiatry and Mental healthmedicine.anatomical_structureMental HealthTreatment OutcomeCardiologyRegression AnalysisCognitive SciencesFemaleClinical psychologyResearch PaperAdultmedicine.medical_specialtyClinical SciencesCreatinebehavioral disciplines and activitiesGyrus Cinguli03 medical and health sciencesNeurochemicalClinical ResearchInternal medicinemental disordersHumansBiological PsychiatryAnterior cingulate cortexPsychiatric Status Rating ScalesDepressive DisorderDepressive Disorder Majorbusiness.industryNeurosciencesMajor030227 psychiatryBrain DisordersCross-Sectional Studiesnervous systemchemistryBrain stimulationbusiness030217 neurology & neurosurgeryBiomarkersFollow-Up Studies
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