0000000001280369

AUTHOR

Anais Adolle

showing 4 related works from this author

Anticancer Agents: Does a Phosphonium Behave Like a Gold(I) Phosphine Complex? Let a “Smart” Probe Answer!

2015

Gold phosphine complexes, such as auranofin, have been recognized for decades as antirheumatic agents. Clinical trials are now underway to validate their use in anticancer or anti-HIV treatments. However, their mechanisms of action remain unclear. A challenging question is whether the gold phosphine complex is a prodrug that is administered in an inactive precursor form or rather that the gold atom remains attached to the phosphine ligand during treatment. In this study, we present two novel gold complexes, which we compared to auranofin and to their phosphonium analogue. The chosen ligand is a phosphine-based smart probe, whose strong fluorescence depends on the presence of the gold atom. …

Models MolecularBiodistributionAuranofinPhosphinesStereochemistryAntineoplastic AgentsLigandsStructure-Activity Relationshipchemistry.chemical_compoundAuranofinNeoplasmsDrug DiscoveryTumor Cells CulturedZebrafish larvaemedicineAnimalsHumansTissue DistributionPhosphoniumZebrafishCell ProliferationMolecular StructureChemistryLigandProdrugAntirheumatic AgentsLarvaMolecular MedicineGoldPhosphineDerivative (chemistry)medicine.drugJournal of Medicinal Chemistry
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CCDC 1014822: Experimental Crystal Structure Determination

2015

Related Article: Moussa Ali , Lucile Dondaine , Anais Adolle , Carla Sampaio , Florian Chotard , Philippe Richard , Franck Denat , Ali Bettaieb , Pierre Le Gendre , Véronique Laurens , Christine Goze , Catherine Paul , and Ewen Bodio|2015|J.Med.Chem.|58|4521|doi:10.1021/acs.jmedchem.5b00480

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(3-(4-(bis(4-methylphenyl)phosphino)phenyl)-7-methoxy-2H-chromen-2-one)-chloro-gold(i)Experimental 3D Coordinates
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CCDC 1014823: Experimental Crystal Structure Determination

2015

Related Article: Moussa Ali , Lucile Dondaine , Anais Adolle , Carla Sampaio , Florian Chotard , Philippe Richard , Franck Denat , Ali Bettaieb , Pierre Le Gendre , Véronique Laurens , Christine Goze , Catherine Paul , and Ewen Bodio|2015|J.Med.Chem.|58|4521|doi:10.1021/acs.jmedchem.5b00480

Space GroupCrystallography(4-(7-methoxy-2-oxo-2H-chromen-3-yl)phenyl)-methyl-bis(4-methylphenyl)phosphonium iodide dichloromethane solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1014821: Experimental Crystal Structure Determination

2015

Related Article: Moussa Ali , Lucile Dondaine , Anais Adolle , Carla Sampaio , Florian Chotard , Philippe Richard , Franck Denat , Ali Bettaieb , Pierre Le Gendre , Véronique Laurens , Christine Goze , Catherine Paul , and Ewen Bodio|2015|J.Med.Chem.|58|4521|doi:10.1021/acs.jmedchem.5b00480

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters3-(4-(bis(4-methylphenyl)phosphino)phenyl)-7-methoxy-2H-chromen-2-oneExperimental 3D Coordinates
researchProduct