Analysis of Klotho 1 gene variants in not melanocytic skin cancer

Aim of the study: The incidence of the vast majority of cancers, including melanoma and not melanocytic skin cancer (NMSC) increases with advancing age. However, the mechanism by which aging influences the risk of developing cancer is not fully understood. Whether this is attributable to declines in immunity or other changes, such as changes in the aging microenvironment, remains unclear. Amongst the many proteins implicated in aging is the protein Klotho. Loss of Klotho function results in the early appearance of several pathologies associated with human aging, downregulation of Klotho was found in several cancers, such as pancreatic cancer, HCC, and other tumors. Downregulation of Klotho …

EFFETTI DELL'INCISIONE ANULARE SUL COMPORTAMENTO VEGETO-PRODUTTIVO DELLA CULTIVAR DI UVA DA TAVOLA VITTORIA

The dissolution of gypsum of Disueri reservoir left bank

Results of a laboratory research programme on the rate of dissolution of selenitic gypsum are reported and discussed. The tested gypsum samples have been recovered from boreholes drilled in a thick layer outcropping on the left bank of Disueri reservoir located near Gela in Sicily. The tests carried out demonstrate that the rate of dissolution Rd depends essentially upon the velocity v of water flowing over the surface of the gypsum. Values of Rd range from 0.94 to 3 kg/(m2 • day) for v values from 0.05 to 0.20 m/s. Such high rates can account both for the rapid evolution of the existing cavities and for the creation of new caves within the gypsum mass subsequent to the impounding of the re…