0000000001290521

AUTHOR

Matthieu Foll

0000-0001-9006-8436

showing 1 related works from this author

A Novel Risk Locus at 6p21.3 for Epstein-Barr Virus-Positive Hodgkin Lymphoma

2015

Abstract Background: A proportion of the genetic variants involved in susceptibility to Hodgkin lymphoma differ by the tumor's Epstein–Barr virus (EBV) status, particularly within the MHC region. Methods: We have conducted an SNP imputation study of the MHC region, considering tumor EBV status in 1,200 classical Hodgkin lymphoma (cHL) cases and 5,726 control subjects of European origin. Notable findings were genotyped in an independent study population of 468 cHL cases and 551 controls. Results: We identified and subsequently replicated a novel association between a common genetic variant rs6457715 and cHL. Although strongly associated with EBV-positive cHL [OR, 2.33; 95% confidence interva…

MaleEpstein-Barr Virus InfectionsEpidemiologyGenome-wide association studySUSCEPTIBILITYDISEASEMajor Histocompatibility Complex0302 clinical medicineNodular sclerosishemic and lymphatic diseasespolycyclic compoundsNetherlandsAged 80 and over0303 health scienceseducation.field_of_study[SDV.MHEP] Life Sciences [q-bio]/Human health and pathologyfood and beveragesMiddle AgedHodgkin Disease3. Good healthOncology030220 oncology & carcinogenesisUrological cancers Radboud Institute for Health Sciences [Radboudumc 15]Chromosomes Human Pair 6FemaleINFECTIOUS-MONONUCLEOSISSUBTYPEAdultAdolescentPopulationLocus (genetics)macromolecular substancesBiologyScandinavian and Nordic CountriesPolymorphism Single NucleotideSEQUENCE03 medical and health sciencesYoung AdultEBVmedicineSNPHumansGenetic Predisposition to DiseaseGENOME-WIDE ASSOCIATIONeducationEpstein–Barr virus infection030304 developmental biologyAgedCase-control studyEpstein-Barr Virus Positivemedicine.diseaseCase-Control StudiesImmunology[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyCancer Epidemiology Biomarkers & Prevention
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