0000000001292936

AUTHOR

William Hagopian

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Antibodies to New Beta Cell Antigen ICA12 in Latvian Diabetes Patients

2006

In Latvia diabetes mellitus is diagnosed using the WHO's clinical criteria, and assays for the detection of autoantibodies are not available. In consequence, slowly progressive autoimmune diabetes or LADA is likely to be missed. Antibodies to GAD65 and IA-2 are the major immunological markers in autoimmune diabetes. Recently, a new beta cell antigen, called ICA12, has been identified, which has a homology to the SOX family of transcription factors. The aim of the study was to analyze the prevalence of ICA12 antibodies in diabetes mellitus patients and controls from Latvia and to see whether this antigen is important in revealing autoimmunity when antibodies against major antigens are not pr…

Maleendocrine systemAdolescentendocrine system diseasesmedicine.disease_causeAutoantigensGeneral Biochemistry Genetics and Molecular BiologyAutoimmunityIslets of LangerhansHistory and Philosophy of ScienceAntigenHLA-DQ AntigensDiabetes mellitusmedicineHumansChildAutoantibodiesgeographygeography.geographical_feature_categorybiologyGlutamate Decarboxylasebusiness.industryGeneral NeuroscienceHigh Mobility Group ProteinsAutoantibodyInfantnutritional and metabolic diseasesmedicine.diseaseIsletLatviaIsoenzymesDiabetes Mellitus Type 2Child PreschoolAutoimmune diabetesImmunologybiology.proteinFemaleDisease SusceptibilityBeta cellAntibodybusinessSOXD Transcription FactorsBiomarkersAnnals of the New York Academy of Sciences
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