0000000001294129
AUTHOR
Antonio Carlino
showing 10 related works from this author
Application of Electron Spin Resonance technique in neutron dosimetry
2012
Along with the Neutron Capture Therapy (NCT) development and with the use of thermal neutrons for radiotherapeutic purposes, many efforts have been devoted to the beam characterization in order to optimize the therapy procedures. Reliable dosimetric measurements should be able to determine the various components (neutronic and photonic) of the mixed beam usually employed for therapy [1]. We have studied the effect of the additive such as gadolinium and 10B-boric acid on the neutron sensitivity of alanine ESR dosimeters exposed to a gamma and mixed (n, gamma) field mainly composed by thermal neutrons. We have chosen both this additive nuclei because of their very high capture cross section t…
Dosimetria ESR con alanina per adronterapia per protoni e ioni carbonio
2014
DOSIMETRIA DI FASCI NEUTRONICI TRAMITE SPETTROSCOPIA DI RISONANZA PARAMAGNETICA ELETTRONICA (EPR)
2013
12C ion beam dose distribution in presence of medium inhomogeneities: comparison between different measurements and simulations with the treatment pl…
2012
Heavy-ions beams offer several advantages compared to other radiation such as low lateral scattering and high biological effectiveness (RBE) in the Bragg peak region, making them particularly attractive for the treatment of radio-resistant tumours localized close to organs at risk [1]. The extension of ion therapy to new clinical cases requires the exploitation of a dedicated treatment planning system (TPS) based on the existing version of TRiP98 [2,3], established TPS for carbon ions. The theoretical models and experimental databases included in TRiP98 are presently mainly based on measurements in water. This approximation can be applied successfully to reproduce many biological tissues wi…
DOSIMETRIA ESR CON ALANINA PER ADRONTERAPIA CON IONI CARBONIO
2015
La sicurezza del paziente sottoposto a trattamenti terapeutici con radiazioni ionizzanti e il buon esito degli ultimi sono strettamente legati all’ottimizzazione delle procedure di esposizione alle radiazioni ionizzanti. In particolare è fondamentale arrecare il danno minore possibile ai tessuti sani che circondano la neoplasia da trattare. Rispetto ai campi di radiazione convenzionali utilizzati in radioterapia (fotoni), le particelle cariche pesanti (protoni e ioni carbonio) offrono diversi vantaggi quali la bassa dispersione laterale, l’alta efficacia biologica (RBE) nella regione del picco di Bragg ed un profilo di dose caratteristico in profondità del tutto differente da quello dei fot…
Dosimetria EPR con alanina per fasci di protoni per adronterapia
2013
Alanine/ESR dosimetry for electron Intra-Operative RadioTherapy: output factor measurements and Monte Carlo-GEANT4 simulations for IORT mobile dedica…
2015
Intra-operative radiation therapy (IORT) is a treatment modality where a single high dose of radiation is delivered directly to the tumor bed or to the exposed tumor during the surgical intervention, while avoiding surrounding dose-limiting structures. Mobile electron linear accelerators dedicated to IORT have been manufactured which have promoted a local large diffusion of this radiotherapy modality. For breast irradiation, a single fraction of 21 Gy delivered on the target volume during the surgical procedure is equivalent to the total dosage (60 Gy) usually delivered during 30 external fractionated radiotherapy at 2Gy/fraction. Alternatively, a single dose of 10 Gy can be administered as…
Characterization of alanine EPR detectors response in clinical carbon ion beams
2012
Heavy-ions beams offer several advantages compared to other radiation such as low lateral scattering and high biological effectiveness (RBE) in the Bragg peak region, making them particularly attractive for the treatment of radio-resistant tumors localized close to organs at risk [1]. Although ion beam radiotherapy ultimately requires dose prescription in terms of biological dose or cell survival, absorbed dose is still the quantity mostly used in clinical quality assurance and to dosimetrically characterize the beam. Moreover, the nuclear projectile fragmentation of heavy ions because of inelastic nuclear interactions with medium produces secondary particles with lower Z. The detailed know…
Alanine EPR pellets for dosimetry of clinical proton and carbon ion beams
2015
The main gol of the present work is to investigate the response behaviour of alanine EPR pellets in clinical proton anc carbon ion beams. Proton irradiations were carried out at PSI (Switzerland) using both passive and active scattering modality, whereas, C ions irradiation were performed at GSI (Germany) adopting the raster scanning modality.