0000000001294676
AUTHOR
Véronique Perrier
showing 3 related works from this author
Conical nanopores highlight the pro-aggregating effects of pyrimethanil fungicide on Aβ(1-42) peptides and dimeric splitting phenomena.
2022
International audience; The Aβ(1-42) aggregation is a key event in the physiopathology of Alzheimer's disease (AD). Exogenous factors such as environmental pollutants, and more particularly pesticides, can corrupt Aβ(1-42) assembly and could influence the occurrence and pathophysiology of AD. However, pesticide involvement in the early stages of Aβ(1-42) aggregation is still unknown. Here, we employed conical track-etched nanopore in order to analyse the Aβ(1-42) fibril formation in the presence of pyrimethanil, a widely used fungicide belonging to the anilinopyrimidine class. Our results evidenced a pro-aggregating effect of pyrimethanil on Aβ(1-42). Aβ(1-42) assemblies were successfully d…
Detection of Amyloid-β Fibrils Using Track-Etched Nanopores: Effect of Geometry and Crowding
2021
Several neurodegenerative diseases have been linked to proteins or peptides that are prone to aggregate in different brain regions. Aggregation of amyloid-β (Aβ) peptides is recognized as the main cause of Alzheimer's disease (AD) progression, leading to the formation of toxic Aβ oligomers and amyloid fibrils. The molecular mechanism of Aβ aggregation is complex and still not fully understood. Nanopore technology provides a new way to obtain kinetic and morphological aspects of Aβ aggregation at a single-molecule scale without labeling by detecting the electrochemical signal of the peptides when they pass through the hole. Here, we investigate the influence of nanoscale geometry (conical an…
Le processus d'auto-sélection des filles à l'entrée en première
1993
International audience; Le niveau de la classe de seconde appara\ⁱt tout à fait déterminant dans la différenciation des carrières scolaires avec en particulier l'émergence de différences entre garçons et filles. Cette recherche se centre sur les mécanismes qui produisent ces différences, et notamment le moindre accès des filles à la première S. Il ressort, sur ce dernier point, que la situation des filles ne renvoie pas à des résultats plus faibles dans les matières scientifiques. Au contraire, les filles devraient plus fréquemment que les garçons accéder à la 1ere S si l'orientation dans cette classe ne dépendait que des notes et des progressions dans les différentes matières. En fait, le …