0000000001295881
AUTHOR
J. Ignacio Casal
Release of Hypoacetylated and Trimethylated Histone H4 Is an Epigenetic Marker of Early Apoptosis
11 p.-5 fig.-1 fig. supl.
Spanish human proteome project: Dissection of chromosome 16
11 páginas, 6 figuras.-- et al.
A multicentric study to evaluate the use of relative retention times in targeted proteomics.
Despite the maturity reached by targeted proteomic strategies, reliable and standardized protocols are urgently needed to enhance reproducibility among different laboratories and analytical platforms, facilitating a more widespread use in biomedical research. To achieve this goal, the use of dimensionless relative retention times (iRT), defined on the basis of peptide standard retention times (RT), has lately emerged as a powerful tool. The robustness, reproducibility and utility of this strategy were examined for the first time in a multicentric setting, involving 28 laboratories that included 24 of the Spanish network of proteomics laboratories (ProteoRed-ISCIII). According to the results…
Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis
6 p.-2 fig.-2 tab.