0000000001296366

AUTHOR

E. Malfatto

showing 2 related works from this author

Ceftolozane/Tazobactam for Treatment of Severe ESBL-Producing

2020

Abstract Background Few data are reported in the literature about the outcome of patients with severe extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) infections treated with ceftolozane/tazobactam (C/T), in empiric or definitive therapy. Methods A multicenter retrospective study was performed in Italy (June 2016–June 2019). Successful clinical outcome was defined as complete resolution of clinical signs/symptoms related to ESBL-E infection and lack of microbiological evidence of infection. The primary end point was to identify predictors of clinical failure of C/T therapy. Results C/T treatment was documented in 153 patients: pneumonia was the most common diagnosis (n = 46…

medicine.medical_specialtyceftolozane/tazobactammedicine.medical_treatmentCRRTTazobactamEnterobacteralesEnterobacteraleInternal medicineCRRT; ESBL; Enterobacterales; ceftolozane/tazobactam; septic shockMajor ArticlemedicineClinical endpointRenal replacement therapybusiness.industrySeptic shockRetrospective cohort studyOdds ratiomedicine.diseaseCeftolozane/tazobactam; CRRT; Enterobacterales; ESBL; Septic shockAcademicSubjects/MED00290Infectious DiseasesOncologyESBLseptic shockCeftolozanebusinessEmpiric therapymedicine.drugOpen forum infectious diseases
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Effectiveness of a project to prevent HIV vertical transmission in the Republic of Congo

2013

OBJECTIVES: To evaluate the effectiveness of a prevention programme against the vertical transmission of HIV in a resource-limited setting and to investigate variables associated with compliance. PATIENTS AND METHODS: The Kento-Mwana project (2005-2008) provided counselling, serological and biomolecular testing and prophylaxis/therapy to HIV-positive pregnant women and their children attending four antenatal clinics in Pointe Noire, Republic of Congo. Expected and actual rates of vertical transmission of HIV were compared. Univariate and multivariate analyses were performed in order to identify variables associated with non-compliance. RESULTS: The observed transmission rate in the group wh…

MaleInfectious Disease TransmissionPMTCTHuman immunodeficiency virus (HIV)HIV Infectionsmedicine.disease_causeSettore MED/42 - Igiene Generale E Applicatalaw.inventionlawPregnancyVerticalPharmacology (medical)Prospective StudiesPregnancy Complications InfectiousProspective cohort studyAttrition; Drop-out; Lost to follow-up; Mother-to-child transmission; PMTCT; Congo; Female; HIV Infections; Humans; Infant; Infant Newborn; Infectious Disease Transmission Vertical; Male; Patient Acceptance of Health Care; Patient Compliance; Pregnancy; Pregnancy Complications Infectious; Prospective Studies; Health Services Research; Pharmacology; Pharmacology (medical); Infectious DiseasesInfectiousdrop-outTransmission (mechanics)Infectious DiseasesCongoFemaleHealth Services ResearchMicrobiology (medical)attritionHIV prevention; vertical transmission; republic of CongoTransmission rateHIV preventionTarget populationPrenatal caremedicineHumansLost to follow-upPharmacologylost to follow-upPregnancybusiness.industryInfant Newbornmother-to-child transmissionInfantrepublic of CongoPatient Acceptance of Health Caremedicine.diseaseNewbornInfectious Disease Transmission VerticalPregnancy ComplicationsImmunologyPatient Compliancevertical transmissionbusinessDemography
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