Author: Anna Olejniczak

0000000001298810

AUTHOR

Anna Olejniczak

Pressure-Stabilized Solvates of Xylazine Hydrochloride

High pressure strongly favors the highest-density polymorph Z of active pharmaceutical ingredient 2-(2,6-xylidino)-5,6-dihydro-4H-1,3-thiazine hydrochloride (xylazine hydrochloride, XylHCl) up to about 0.1 GPa only, but still higher pressure destabilizes this structure. Above 0.1 GPa, XylHCl preferentially crystallizes as solvates with CH2Cl2, CHCl3, or (CH3)2CHOH depending on the solvent used. However, when XylHCl·H2O is dissolved in any of these solvents, the high-pressure crystallizations yield the hydrate XylHCl·H2O only. The single crystals of the CH2Cl2, CHCl3, and (CH3)2CHOH solvates could be grown in situ in a diamond anvil cell, which allowed their structure determination from the …

0000000001298810

AUTHOR

Anna Olejniczak

Pressure-Stabilized Solvates of Xylazine Hydrochloride

CCDC 1454091: Experimental Crystal Structure Determination

CCDC 1454081: Experimental Crystal Structure Determination

CCDC 1454078: Experimental Crystal Structure Determination

CCDC 1454087: Experimental Crystal Structure Determination

CCDC 1454090: Experimental Crystal Structure Determination

CCDC 1454088: Experimental Crystal Structure Determination

CCDC 1454089: Experimental Crystal Structure Determination

CCDC 1454079: Experimental Crystal Structure Determination

CCDC 1454080: Experimental Crystal Structure Determination

CCDC 1454085: Experimental Crystal Structure Determination

CCDC 1454086: Experimental Crystal Structure Determination

CCDC 1454084: Experimental Crystal Structure Determination

CCDC 1454082: Experimental Crystal Structure Determination

CCDC 1454083: Experimental Crystal Structure Determination