0000000001299010
AUTHOR
Alexander Pöthig
Highly-fluorescent BODIPY-functionalised metallacages as drug delivery systems
With the aim of designing new metallosupramolecular architectures for drug delivery, research has focused on porous 3-dimensional (3D)-metallacages able to encapsulate cytotoxic agents protecting them from metabolism while targeting them to cancer sites. Here, two self-assembled [Pd2L4]4+ cages (CG1 and CG2) featuring 3,5-bis(3-ethynylpyridine)phenyl ligands (L) exo-functionalised with dipyrromethene (BODIPY) groups have been synthesised and characterised by different methods, including NMR spectroscopy and mass spectrometry. 1H NMR spectroscopy studies shows that the cages are able to encapsulate the anticancer drug cisplatin in their hydrophobic cavity, as evidenced by electrostatic poten…
C−C Cross-Couplings from a Cyclometalated Au(III) C∧ N Complex: Mechanistic Insights and Synthetic Developments
Abstract In recent years, the reactivity of gold complexes was shown to extend well beyond π‐activation and to hold promises to achieve selective cross‐couplings in several C−C and C−E (E=heteroatom) bond forming reactions. Here, with the aim of exploiting new organometallic species for cross‐coupling reactions, we report on the Au(III)‐mediated C(sp2)−C(sp) occurring upon reaction of the cyclometalated complex [Au(CCH2N)Cl2] (1, CCH2N=2‐benzylpyridine) with AgPhCC. The reaction progress has been monitored by NMR spectroscopy, demonstrating the involvement of a number of key intermediates, whose structures have been unambiguously ascertained through 1D and 2D NMR analyses (1H, 13C, 1H‐1H CO…
Exploring the Reactivity and Biological Effects of Heteroleptic N-Heterocyclic Carbene Gold(I)- Alkynyl Complexes
With the aim to explore the effects of different organometallic ligands on the reactivity and biological properties of a series of twelve heteroleptic AuI complexes, of general formula [Au(NHC)(alkynyl)] (NHC = benzimidazolylidene or 1,3-dihydroimidazolylidene) were synthesized and characterized by 1H and 13C NMR and elemental analysis, and in some cases also by X-ray diffraction. The compounds were all stable in H2O/DMSO as established by NMR spectroscopy, while they could react with model thiols (EtSH) in the presence of water to undergo ligand-substitution reactions. 1H NMR experiments showed that dissociation of the more labile alkynyl ligand was possible for all compounds, while in the…
CCDC 1955879: Experimental Crystal Structure Determination
Related Article: Jens Oberkofler, Brech Aikman, Riccardo Bonsignore, Alexander Pöthig, James Platts, Angela Casini, Fritz E. Kühn|2020|Eur.J.Inorg.Chem.|2020|1040|doi:10.1002/ejic.201901043
CCDC 2143205: Experimental Crystal Structure Determination
Related Article: Brech Aikman, Riccardo Bonsignore, Ben Woods, Daniel Doellerer, Riccardo Scotti, Claudia Schmidt, Alexandra A. Heidecker, Alexander Pöthig, Edward J. Sayers, Arwyn T. Jones, Angela Casini|2022|Dalton Trans.|51|7476|doi:10.1039/D2DT00337F
CCDC 1955877: Experimental Crystal Structure Determination
Related Article: Jens Oberkofler, Brech Aikman, Riccardo Bonsignore, Alexander Pöthig, James Platts, Angela Casini, Fritz E. Kühn|2020|Eur.J.Inorg.Chem.|2020|1040|doi:10.1002/ejic.201901043
CCDC 2082254: Experimental Crystal Structure Determination
Related Article: Riccardo Bonsignore, Sophie R. Thomas, Mathilde Rigoulet, Christian Jandl, Alexander Pöthig, Didier Bourissou, Giampaolo Barone, Angela Casini|2021|Chem.-Eur.J.|27|14322|doi:10.1002/chem.202102668
CCDC 1955875: Experimental Crystal Structure Determination
Related Article: Jens Oberkofler, Brech Aikman, Riccardo Bonsignore, Alexander Pöthig, James Platts, Angela Casini, Fritz E. Kühn|2020|Eur.J.Inorg.Chem.|2020|1040|doi:10.1002/ejic.201901043
CCDC 1955876: Experimental Crystal Structure Determination
Related Article: Jens Oberkofler, Brech Aikman, Riccardo Bonsignore, Alexander Pöthig, James Platts, Angela Casini, Fritz E. Kühn|2020|Eur.J.Inorg.Chem.|2020|1040|doi:10.1002/ejic.201901043
CCDC 2082253: Experimental Crystal Structure Determination
Related Article: Riccardo Bonsignore, Sophie R. Thomas, Mathilde Rigoulet, Christian Jandl, Alexander Pöthig, Didier Bourissou, Giampaolo Barone, Angela Casini|2021|Chem.-Eur.J.|27|14322|doi:10.1002/chem.202102668
CCDC 2096758: Experimental Crystal Structure Determination
Related Article: Riccardo Bonsignore, Sophie R. Thomas, Mathilde Rigoulet, Christian Jandl, Alexander Pöthig, Didier Bourissou, Giampaolo Barone, Angela Casini|2021|Chem.-Eur.J.|27|14322|doi:10.1002/chem.202102668
CCDC 1955878: Experimental Crystal Structure Determination
Related Article: Jens Oberkofler, Brech Aikman, Riccardo Bonsignore, Alexander Pöthig, James Platts, Angela Casini, Fritz E. Kühn|2020|Eur.J.Inorg.Chem.|2020|1040|doi:10.1002/ejic.201901043