0000000001299664

AUTHOR

Kārlis Bērziņš

showing 16 related works from this author

Solvates of Dasatinib: Diversity and Isostructurality

2015

A series of dasatinib crystalline forms were obtained, and a hierarchical cluster analysis of their powder X-ray diffraction patterns was performed. The resulting dendrogram implies 3 structural groups. The crystal structures of several solvates representing 2 of these groups were determined. The crystal structure analysis confirms the isostructurality of solvates within structural group I and suggests a correlation between solvent molecule size and trends in crystal structures within this group. In addition, the formation relationships in 2-solvent media between different dasatinib solvate groups were determined. The formation preference of solvates was found to follow the ranking group I …

Models MolecularStereochemistryGroup iiDasatinibPharmaceutical ScienceAntineoplastic Agents02 engineering and technologyCrystal structure010402 general chemistry01 natural scienceslaw.inventionX-Ray DiffractionlawGroup (periodic table)medicineCluster AnalysisCrystallizationChemistrySolvation021001 nanoscience & nanotechnology0104 chemical sciencesDasatinibCrystallographyX-ray crystallographyCrystallization0210 nano-technologyPowder DiffractionPowder diffractionmedicine.drugJournal of Pharmaceutical Sciences
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The influence of pH on the stability of antazoline: kinetic analysis

2015

Degradation of the drug antazoline was studied in aqueous solutions by means of pH-rate profiling (pH 0–7.4). The novel approach of Runge–Kutta numerical integration in combination with multi-parameter optimisation was applied to UV-Vis spectral data to determine a valid kinetic model and kinetic parameters of the degradation process. The overall degradation mechanism was found to be dependent on the environmental pH. In the pH range of 3.0–7.4, the formation of the antazoline hydrolysis product (N-(2-aminoethyl)-2-(N-benzylanilino)acetamide) through three different pathways (acidic, non-catalysed, and semi-alkaline hydrolysis) was observed. In highly acidic media (pH 0–2), the degradation …

Aqueous solutionChemistryGeneral Chemical EngineeringKinetic analysisInorganic chemistryAnalytical chemistryGeneral ChemistryKinetic energyHigh-performance liquid chromatographychemistry.chemical_compoundHydrolysisAntazolinemedicineSpectral dataAcetamidemedicine.drugRSC Advances
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Multi-technique approach for qualitative and quantitative characterization of furazidin degradation kinetics under alkaline conditions

2016

Degradation of drug furazidin was studied under different conditions of environmental pH (11-13) and temperature (30-60°C). The novel approach of hybrid hard- and soft-multivariate curve resolution-alternating least squares (HS-MCR-ALS) method was applied to UV-vis spectral data to determine a valid kinetic model and kinetic parameters of the degradation process. The system was found to be comprised of three main species and best characterized by two consecutive first-order reactions. Furazidin degradation rate was found to be highly dependent on the applied environmental conditions, showing more prominent differences between both degradation steps towards higher pH and temperature. Complim…

Clinical BiochemistryAnalytical chemistryPharmaceutical ScienceHydantoin02 engineering and technologyDerivativeKinetic energy01 natural sciencesLeast squaresMass SpectrometrySpectral lineAnalytical ChemistryHydrolysischemistry.chemical_compoundUltraviolet visible spectroscopyDrug DiscoverySpectroscopyFuraginHydrolysis010401 analytical chemistryTemperatureHydrogen-Ion Concentration021001 nanoscience & nanotechnology0104 chemical sciencesKineticschemistryDegradation (geology)Spectrophotometry Ultraviolet0210 nano-technologyJournal of Pharmaceutical and Biomedical Analysis
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Kapitāla augļi kā ražošanas izmaksa

1933

Saturs (nodaļas): I. Ievads. II. Vai kapitāla augļi ir izmaksas sastāvdaļa? III. Kapitāla augļi pašizmaksas un rezultātu aplēsēs. IV. Kapitāla augļu kā izmaksas sastāvdaļas aplēšana un grāmatošana. V. Slēdziens. Die Kapitalzinsen als Produktionskosten (Zusammenfassung)

IzmaksasSelbstkostenrechnungGrāmatvedībaEkonomikaKapitālsIzmaksu uzskaiteCost accountingPrivātsaimniecībasProduktionskostenBetriebsrechnung.:SOCIAL SCIENCES::Business and economics::Economics [Research Subject Categories]BuchhaltungslehreUnternehmungskapitalKapitalzinsenSaimnieciskais aprēķins
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Furazidīna stabilitāte šķīdumos

2014

Furazidīna stabilitāte šķīdumos. Bērziņš K., zinātniskais vadītājs Prof. Dr. ķīm. Andris Actiņš, konsultants Mag. ķīm. Ilze Grante, Maģistra darbs, 41 lapaspuse, 21 attēls, 8 tabulas, 43 literatūras avoti, 4 pielikumi. Latviešu valodā. Literatūras apskatā apkopota informācija par farmaceitiski aktīvo vielu degradāciju un to pētīšanas metodēm šķīdumos – UV/VIS spektroskopiju un augsti efektīvo šķīdrumu hromatogrāfiju-masspektrometriju; kompleksu sistēmu reakciju kinētiku homogēnā vidē. Veikti spektroskopiski furazidīna degradācijas pētījumi etanolā un bāziskos ūdens šķīdumos; hromatogrāfiski pētīta furazidīna bāzisku ūdens šķīdumu degradācijas dinamika un veikta komponentu kvalitatīvā analīz…

Ķīmija
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Latvijas Universitātes tautsaimniecības un tiesību zinātņu fakultātes bibliotēkas sistēmatiskais katalogs, 1. sēj.

1930

Sistemātiskais katalogs - kopējā nodaļaSistemātiskais katalogs - tautsaimniecības nodaļaLibrary catalogsSistemātiskais katalogs - tiesību zinātņu nodaļaBibliotēku katalogiSystematic catalogLatvijas Universitātes vēstureSistemātiskais katalogs (Latvijas Universitātes Tautsaimniecības un tiesību zinātņu fakultātes Bibliotēka):SOCIAL SCIENCES::Other social sciences::Library and information science [Research Subject Categories]
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CCDC 910846: Experimental Crystal Structure Determination

2016

Related Article: Kārlis Bērziņš, Artis Kons, Ilze Grante, Diana Dzabijeva, Ilva Nakurte, Andris Actiņš|2016|J.Pharm.Biomed.Anal.|129|433|doi:10.1016/j.jpba.2016.07.039

Space GroupCrystallography1-((3-(5-nitro-2-furyl)prop-2-en-1-ylidene)amino)imidazolidine-24-dione tetrahydrofuran solvate monohydrateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1420813: Experimental Crystal Structure Determination

2018

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

Space GroupCrystallographyN-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-13-thiazole-5-carboxamide dimethyl sulfoxide solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1420812: Experimental Crystal Structure Determination

2018

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-13-thiazole-5-carboxamide propan-2-ol solvateExperimental 3D Coordinates
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CCDC 1420811: Experimental Crystal Structure Determination

2018

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-13-thiazole-5-carboxamide isopropyl acetate solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1420810: Experimental Crystal Structure Determination

2018

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-13-thiazole-5-carboxamide 14-dioxane solvateExperimental 3D Coordinates
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CCDC 1420814: Experimental Crystal Structure Determination

2018

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-13-thiazole-5-carboxamide butyl acetate solvateExperimental 3D Coordinates
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CCDC 1420809: Experimental Crystal Structure Determination

2018

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-13-thiazole-5-carboxamide butan-1-ol solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 910834: Experimental Crystal Structure Determination

2016

Related Article: Kārlis Bērziņš, Artis Kons, Ilze Grante, Diana Dzabijeva, Ilva Nakurte, Andris Actiņš|2016|J.Pharm.Biomed.Anal.|129|433|doi:10.1016/j.jpba.2016.07.039

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters1-((3-(5-nitro-2-furyl)prop-2-en-1-ylidene)amino)imidazolidine-24-dione NN-dimethylformamide solvate monohydrateExperimental 3D Coordinates
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CCDC 1420807: Experimental Crystal Structure Determination

2018

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

Space GroupCrystallographyCrystal SystemCrystal StructureN-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-13-thiazole-5-carboxamide acetone solvateCell ParametersExperimental 3D Coordinates
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CCDC 1420808: Experimental Crystal Structure Determination

2018

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

Space GroupCrystallographyCrystal SystemCrystal StructureN-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-13-thiazole-5-carboxamide ethanol solvateCell ParametersExperimental 3D Coordinates
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