Author: M. Haukka

0000000001299876

AUTHOR

M. Haukka

One-Pot Synthesis, X-ray Single Crystal and Molecular Insight of Enaminone-Based β-Morpholino-/N-Methylpiperazinyl-/Pyrrolidinylpropiophenone

One-pot synthesis of three enaminones, (E)-1-(4-chlorophenyl)-3-morpholinoprop-2-en-1-one 1, (E)-1-(4-chlorophenyl)-3-(4-methylpiperazin-1-yl)prop-2-en-1-one 2, and (E)-1-(4-chlorophenyl)-3-(pyrrolidin-1-yl)prop-2-en-1-one 3 were achieved. The synthetic protocol via three components reaction of p-chloroacetophenone with DMFDMA (N,N-dimethylformamid-dimethylacetal) and the corresponding secondary amines (morpholine/N-methylpiperazine/pyrrolidine) in dioxane under heating for 2.5–4 h at 102 °C yielded the requisite enaminones. This protocol has the advantage of no separation of intermediate, no need for column purification with quantitative yield for the target compounds. The chemical feature…

0000000001299876

AUTHOR

M. Haukka

One-Pot Synthesis, X-ray Single Crystal and Molecular Insight of Enaminone-Based β-Morpholino-/N-Methylpiperazinyl-/Pyrrolidinylpropiophenone

CCDC 1034603: Experimental Crystal Structure Determination

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CCDC 637411: Experimental Crystal Structure Determination

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CCDC 984540: Experimental Crystal Structure Determination

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CCDC 902349: Experimental Crystal Structure Determination

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CCDC 871907: Experimental Crystal Structure Determination

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CCDC 299923: Experimental Crystal Structure Determination

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CCDC 956724: Experimental Crystal Structure Determination

CCDC 968918: Experimental Crystal Structure Determination

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CCDC 872003: Experimental Crystal Structure Determination

CCDC 914261: Experimental Crystal Structure Determination

CCDC 881311: Experimental Crystal Structure Determination

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CCDC 1434350: Experimental Crystal Structure Determination

CCDC 299921: Experimental Crystal Structure Determination

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CCDC 2120378: Experimental Crystal Structure Determination

CCDC 1034600: Experimental Crystal Structure Determination

CCDC 1893862: Experimental Crystal Structure Determination

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CCDC 978372: Experimental Crystal Structure Determination

CCDC 939036: Experimental Crystal Structure Determination

CCDC 872001: Experimental Crystal Structure Determination

CCDC 796685: Experimental Crystal Structure Determination

CCDC 1034602: Experimental Crystal Structure Determination

CCDC 299920: Experimental Crystal Structure Determination

CCDC 637414: Experimental Crystal Structure Determination

CCDC 1026710: Experimental Crystal Structure Determination

CCDC 1528786: Experimental Crystal Structure Determination

CCDC 988598: Experimental Crystal Structure Determination

CCDC 957341: Experimental Crystal Structure Determination

CCDC 1528784: Experimental Crystal Structure Determination

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CCDC 1507870: Experimental Crystal Structure Determination

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CCDC 978501: Experimental Crystal Structure Determination

CCDC 299924: Experimental Crystal Structure Determination

CCDC 881318: Experimental Crystal Structure Determination

CCDC 957340: Experimental Crystal Structure Determination

CCDC 914350: Experimental Crystal Structure Determination

CCDC 1404151: Experimental Crystal Structure Determination

CCDC 881317: Experimental Crystal Structure Determination

CCDC 914203: Experimental Crystal Structure Determination

CCDC 1507873: Experimental Crystal Structure Determination

CCDC 1528785: Experimental Crystal Structure Determination

CCDC 886202: Experimental Crystal Structure Determination