0000000001299983

AUTHOR

H. Blackburn

showing 4 related works from this author

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

2019

Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the genetic architecture of the trait remains largely unknown. The recent development of machine learning (ML) approaches incited us to apply them to classify healthy and diseased people according to their genomic information. The Immunochip dataset containing 18,227 CD patients and 34,050 healthy controls enrolled and genotyped by the international Inflammatory Bowel Disease genetic consortium (IIBDGC) has been re-analyzed using a set of ML methods: penalized logistic regression (LR), gradient boosted trees (GBT) and artificial neural ne…

Male/692/4020/1503/257/1402GenotypeGenotyping TechniquesLOCI/45/43lcsh:MedicinePolymorphism Single NucleotideCrohn's disease genetics genome wide associationArticleDeep LearningCrohn DiseaseINDEL MutationGenetics researchHumansgeneticsGenetic Predisposition to Disease/129lcsh:ScienceAllelesScience & Technologygenome wide associationRISK PREDICTION/45Models Geneticlcsh:RDecision Trees/692/308/2056ASSOCIATIONMultidisciplinary SciencesCrohn's diseaseLogistic ModelsNonlinear DynamicsROC CurveArea Under CurveScience & Technology - Other Topicslcsh:QFemaleNeural Networks ComputerINFLAMMATORY-BOWEL-DISEASEGenome-Wide Association StudyScientific Reports
researchProduct

CCDC 116646: Experimental Crystal Structure Determination

2000

Related Article: H.Blackburn, J.C.Fettinger, H.-B.Kraatz, R.Poli, R.C.Torralba|2000|J.Organomet.Chem.|593|27|doi:10.1016/S0022-328X(99)00292-2

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(mu~3~-Oxo)-bis(mu~2~-chloro)-tris(eta^5^-methylcyclopentadienyl)-trichloro-tritungsten(iv)Experimental 3D Coordinates
researchProduct

CCDC 116645: Experimental Crystal Structure Determination

2000

Related Article: H.Blackburn, J.C.Fettinger, H.-B.Kraatz, R.Poli, R.C.Torralba|2000|J.Organomet.Chem.|593|27|doi:10.1016/S0022-328X(99)00292-2

Space GroupCrystallography(mu~2~-Oxo)-bis(eta^5^-pentamethyl-cyclopentadienyl)-hexachloro-di-tungsten(iv)Crystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 116644: Experimental Crystal Structure Determination

2000

Related Article: H.Blackburn, J.C.Fettinger, H.-B.Kraatz, R.Poli, R.C.Torralba|2000|J.Organomet.Chem.|593|27|doi:10.1016/S0022-328X(99)00292-2

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersfac-(eta^5^-Methylcyclopentadienyl)-trichloro-(12-bis(diphenylphosphino)ethane)-tungsten(iv) dichloromethane solvateExperimental 3D Coordinates
researchProduct