Author: Chong-ock Lee

0000000001300388

AUTHOR

Chong-ock Lee

Synthesis and cytotoxicity of 6,11-Dihydro-pyrido- and 6,11-Dihydro-benzo[2,3-b]phenazine-6,11-dione derivatives

6,11-Dihydro-pyrido[2,3-b]phenazine-6,11-diones and 6,11-dihydro-benzo[2,3-b]phenazine-6,11-diones were synthesized from 6,7-dichloro-5,8-quinolinedione and 2,3-dichloro-1,4-naphthoquinone. The study on the cytotoxicity on these products revealed that the pyridophenazinediones, tetracyclic heteroquinone analogues with three nitrogen atoms exhibited a high cytotoxicity on several human tumor cell lines. Compound 9c and 9e showed in vitro antitumor activity comparable or superior to doxorubicin against the human ovarian tumor cells (SK-OV-3) and the human CNS cells (XF 498). The IC(50) value for compound 9e was 0.06 microM against the human CNS cells (XF 498), which was 2.6 times higher than …

research product

CCDC 196626: Experimental Crystal Structure Determination

Related Article: Young-Shin Kim, Se-Young Park, Hyun-Jung Lee, Myung-Eun Suh, D.Schollmeyer, Chong-Ock Lee|2003|Bioorg.Med.Chem.|11|1709|doi:10.1016/S0968-0896(03)00028-2

research product

CCDC 196625: Experimental Crystal Structure Determination

Related Article: Young-Shin Kim, Se-Young Park, Hyun-Jung Lee, Myung-Eun Suh, D.Schollmeyer, Chong-Ock Lee|2003|Bioorg.Med.Chem.|11|1709|doi:10.1016/S0968-0896(03)00028-2

research product

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
  - PE2_2 Phenomenology of fundamental interactions
  - PE2_3Experimental particle physics with accelerators
  - PE2_4Experimental particle physics without accelerators
  - PE2_6Nuclear, hadron and heavy ion physics
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  - PE2_7Nuclear and particle astrophysics
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  - PE2_10Atomic, molecular physics
  - PE2_11Ultra-cold atoms and molecules
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  - PE2_14Lasers, ultra-short lasers and laser physics
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  - PE2_16Non-linear physics
  - PE2_12Optics, non-linear optics and nano-optics
  - PE2_13Quantum optics and quantum information
  - PE2_15Thermodynamics
- PE1Mathematics
  - PE1_1Logic and foundations
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  - PE1_8Analysis
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  - PE1_15Generic statistical methodology and modelling
  - PE1_4 Algebraic and complex geometry
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  - PE1_5Lie groups, Lie algebras
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- PE3Condensed Matter Physics
  - PE3_1Structure of solids, material growth and characterisation
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  - PE11_5Engineering of composites and hybrid materials
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  - PE11_8Engineering of alternative established or emergent materials
  - PE11_9Nanomaterials engineering, e.g. nanoparticles, nanoporous materials, 1D & 2D nanomaterials
  - PE11_10Soft materials engineering, e.g. gels, foams, colloids
  - PE11_11Porous materials engineering, e.g. covalent-organic, metal-organic, porous aromatic frameworks
  - PE11_12Semi-conducting and magnetic materials engineering
  - PE11_13Metamaterials engineering
  - PE11_14Computational methods for materials engineering
LSLife Sciences
- LS1Molecules of Life: Biological Mechanisms, Structures and Functions
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- LS2Integrative Biology: from Genes and Genomes to Systems
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  - LS4_1Organ and tissue physiology and pathophysiology
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  - LS4_13Other non-communicable diseases (except disorders of the nervous system and immunity-related diseases)
- LS3Cell Biology, Development, Stem Cells and Regeneration
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  - LS3_7Mechanobiology of cells, tissues and organs
  - LS3_8Embryogenesis, pattern formation, morphogenesis
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  - LS3_10Developmental genetics
  - LS3_11Evolution of developmental strategies
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  - LS3_17Theoretical modelling in cellular, developmental and regenerative biology
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SHSocial Sciences and Humanities
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