Author: Simonas Balkaitis

0000000001300405

AUTHOR

Simonas Balkaitis

showing 8 related works from this author

Preparative-Scale Synthesis of Vedejs Chiral DMAP Catalysts

2018

A scalable synthesis of chiral Vedejs-type DMAP catalysts is reported. The key step of the synthesis is amination of the enantiomerically pure 4-chloropyridine derivative using well-defined ZnCl2(amine)2 complexes. A series of Zn(II)–amine complexes have been synthesized to explore the scope of the ZnCl2-mediated amination of 4-halopyridines. Mechanistic studies support a Zn(II)-facilitated nucleophilic aromatic substitution as a plausible mechanism for the chlorine-to-amine exchange.

010405 organic chemistryOrganic Chemistry010402 general chemistry01 natural sciencesCombinatorial chemistry0104 chemical sciencesCatalysischemistry.chemical_compoundchemistryNucleophilic aromatic substitutionpolycyclic compoundsAmine gas treatingDerivative (chemistry)AminationThe Journal of Organic Chemistry

researchProduct

Acylative Dynamic Kinetic Resolution of Secondary Alcohols: Tandem Catalysis by HyperBTM and Bäckvall's Ruthenium Complex.

2021

Non-enzymatic dynamic kinetic resolution (DKR) of secondary alcohols by enantioselective acylation using an isothiourea-derived HyperBTM catalyst and racemization of slowly reacting alcohol by Backvall's ruthenium complex is reported. The DKR approach features high enantioselectivities (up to 99:1), employs easy-to-handle crystalline 4-nitrophenyl isobutyrate as the acylating reagent, and proceeds at room temperature and under an ambient atmosphere. The stereoinduction model featuring cation-π system interactions between the acylated HyperBTM catalyst and π electrons of an alcohol aryl subunit has been elaborated by DFT calculations.

inorganic chemicals010405 organic chemistryArylOrganic ChemistryEnantioselective synthesischemistry.chemical_elementStereoisomerism010402 general chemistry01 natural sciencesCombinatorial chemistryCatalysisRuthenium0104 chemical sciencesRutheniumCatalysisKinetic resolutionAcylationchemistry.chemical_compoundKineticschemistryReagentAlcoholsRacemizationThe Journal of organic chemistry

researchProduct

Otrējo spirtu dinamiskā kinētiskā sadalīšana

2019

Antrinių alkoholių dinaminė kinetinė rezoliucija. Simonas Balkaitis. Darbo vadovas: Dr. chem. Artis Kinēns. Magistrinį darbą sudaro 63 puslapiai, 10 iliustracijų, 31 schema, 14 lentelių, 1 lygtis, 53 literatūros šaltiniai. Darbas parašytas anglų kalba. Pirmiausia buvo ištirta antrinių alkoholių racemizacija įvairių iridžio, rutenio ir geležies katalizatorių pagalba. Tuomet, racemizacijai tinkamiausiuose tirpiklių variantuose buvo tiriama alkoholių kinetinė rezoliucija. Gauti duomenys buvo panaudoti naujos dinaminės kinetinės rezoliucijos procedūros paieškose.

kinetic resolutioniridiumrutheniumracemisationĶīmijaDynamic kinetic resolution

researchProduct