0000000001301219
AUTHOR
I. Pibiri
Synthesis of Fluorinated Bent-Core Mesogens (BCMs) Containing the 1,2,4-Oxadiazole Ring
New fluorinated bent-core mesogens containing the 1,2,4-oxadiazole or 1,2,4-triazole nucleus have been synthesized taking advantage of the ANRORC (Addition of Nucleophile, Ring-Opening, Ring-Closure) reactivity of 5-perfluoroalkyl-1,2,4-oxadiazoles. Physical state changes of the obtained compounds were characterized through DSC, POM, and SAXS. Besides the formation of a smectic mesophase, a novel behavior as organic molecular glass was evidenced for some 1,2,4-oxadiazole derivatives.
Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codons (PTCs) in cystic fibrosis cells
Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells
Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells
Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells Laura Lentini, Raffaella Melfi, Sara Baldassano, Marco Tutone, Aldo Di Leonardo, Andrea Pace, Ivana Pibiri Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo Background and rationale Cystic Fibrosis patients with nonsense mutations in the CFTR gene have a more severe form of the disease. Nonsense mutations represent about 10% of the mutations that affect the CFTR gene and they are frequently associated to the classical F508 mutation (1). A potential treatment for this genetic alteration is to promote the translationa…
Readthrough Inducing Drugs (TRIDs) in human fibroblasts harboring the c.5047 C>T (R1683*) nonsense mutation
Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models
CCDC 633320: Experimental Crystal Structure Determination
Related Article: A.P.Piccionello, I.Pibiri, A.Pace, R.A.Raccuglia, S.Buscemi, N.Vivona, G.Giorgi|2007|Heterocycles|71|1529|doi:10.3987/COM-07-11040
CCDC 633321: Experimental Crystal Structure Determination
Related Article: A.P.Piccionello, I.Pibiri, A.Pace, R.A.Raccuglia, S.Buscemi, N.Vivona, G.Giorgi|2007|Heterocycles|71|1529|doi:10.3987/COM-07-11040
CCDC 630243: Experimental Crystal Structure Determination
Related Article: S.Buscemi, A.Pace, A.P.Piccionello, I.Pibiri, N.Vivona, G.Giorgi, A.Mazzanti, D.Spinelli|2006|J.Org.Chem.|71|8106|doi:10.1021/jo061251e
CCDC 915396: Experimental Crystal Structure Determination
Related Article: M.Saccone,G.Cavallo,P.Metrangolo,A.Pace,I.Pibiri,T.Pilati,G.Resnati,G.Terraneo|2013|CrystEngComm|15|3102|doi:10.1039/C3CE40268A
CCDC 251468: Experimental Crystal Structure Determination
Related Article: J.R.Hanson, P.B.Hitchcock, I.Pibiri, F.Piozzi|2003|J.Chem.Res.||147|doi:10.3184/030823403103173291
CCDC 630242: Experimental Crystal Structure Determination
Related Article: S.Buscemi, A.Pace, A.P.Piccionello, I.Pibiri, N.Vivona, G.Giorgi, A.Mazzanti, D.Spinelli|2006|J.Org.Chem.|71|8106|doi:10.1021/jo061251e
CCDC 245638: Experimental Crystal Structure Determination
Related Article: A.Pace, I.Pibiri, S.Buscemi, N.Vivona, L.Malpezzi|2004|J.Org.Chem.|69|4108|doi:10.1021/jo049814e
CCDC 251467: Experimental Crystal Structure Determination
Related Article: J.R.Hanson, P.B.Hitchcock, I.Pibiri, F.Piozzi|2003|J.Chem.Res.||147|doi:10.3184/030823403103173291
CCDC 245639: Experimental Crystal Structure Determination
Related Article: A.Pace, I.Pibiri, S.Buscemi, N.Vivona, L.Malpezzi|2004|J.Org.Chem.|69|4108|doi:10.1021/jo049814e
CCDC 915397: Experimental Crystal Structure Determination
Related Article: M.Saccone,G.Cavallo,P.Metrangolo,A.Pace,I.Pibiri,T.Pilati,G.Resnati,G.Terraneo|2013|CrystEngComm|15|3102|doi:10.1039/C3CE40268A
CCDC 630241: Experimental Crystal Structure Determination
Related Article: S.Buscemi, A.Pace, A.P.Piccionello, I.Pibiri, N.Vivona, G.Giorgi, A.Mazzanti, D.Spinelli|2006|J.Org.Chem.|71|8106|doi:10.1021/jo061251e
CCDC 251469: Experimental Crystal Structure Determination
Related Article: J.R.Hanson, P.B.Hitchcock, I.Pibiri, F.Piozzi|2003|J.Chem.Res.||147|doi:10.3184/030823403103173291