0000000001301242
AUTHOR
Paul J. Dyson
showing 7 related works from this author
Reactivity of anticancer metallodrugs with serum proteins: New insights from size exclusion chromatography-ICP-MS and ESI-MS
2010
International audience; A method based on the coupling of high resolution size-exclusion liquid chromatography using a polymer stationary phase with inductively coupled plasma mass spectrometry was developed to study the interactions of two metallodrugs - cisplatin and RAPTA-T - with the serum proteins albumin and transferrin. In contrast to previous approaches, the technique allowed the total recovery of the metals from the column and was able to discriminate between the different species of the metallodrugs and their complexes with the proteins at femtomolar detection levels. Metal binding was found to be dependent on the protein concentration and on the incubation time of the sample. Cis…
Palladium(II)-Stabilized Pyridine-2-Diazotates: Synthesis, Structural Characterization, and Cytotoxicity Studies
2018
Well-defined diazotates are scarce. Here we report the synthesis of unprecedented homoleptic palladium(II) diazotate complexes. The palladium(II)-mediated nitrosylation of 2-aminopyridines with NaNO2 results in the formation of metal-stabilized diazotates, which were found to be cytotoxic to human ovarian cancer cells.
Development of Bimetallic Titanocene−Ruthenium−Arene Complexes As Anticancer Agents: Relationships between Structural and Biological Properties
2010
A series of bimetallic titanium-ruthenium complexes of general formula [(η(5)-C(5)H(5))(μ-η(5):κ(1)-C(5)H(4)(CR(2))(n)PR'R'')TiCl(2)](η(6)-p-cymene)RuCl(2) (n = 0, 1, 2 or 4; R = H or Me; R' = H, Ph, or Cy; R'' = Ph or Cy) have been synthesized, including two novel compounds as well as two cationic derivatives of formula [(η(5)-C(5)H(5))(μ-η(5):κ(1)-C(5)H(4)(CH(2))(n)PPh(2))TiCl(2)] [(η(6)-p-cymene)RuCl](BF(4)) (n = 0 or 2). The solid state structure of two of these compounds was also established by X-ray crystallography. The complexes showed a cytotoxic effect on human ovarian cancer cells and were markedly more active than their Ti or Ru monometallic analogues titanocene dichloride and RA…
CCDC 1577120: Experimental Crystal Structure Determination
2018
Related Article: Alexander G. Tskhovrebov, Anna A. Vasileva, Richard Goddard, Tina Riedel, Paul J. Dyson, Vladimir N. Mikhaylov, Tatiyana V. Serebryanskaya, Viktor N. Sorokoumov, Matti Haukka|2018|Inorg.Chem.|57|930|doi:10.1021/acs.inorgchem.8b00072
CCDC 1577119: Experimental Crystal Structure Determination
2018
Related Article: Alexander G. Tskhovrebov, Anna A. Vasileva, Richard Goddard, Tina Riedel, Paul J. Dyson, Vladimir N. Mikhaylov, Tatiyana V. Serebryanskaya, Viktor N. Sorokoumov, Matti Haukka|2018|Inorg.Chem.|57|930|doi:10.1021/acs.inorgchem.8b00072
CCDC 1577118: Experimental Crystal Structure Determination
2018
Related Article: Alexander G. Tskhovrebov, Anna A. Vasileva, Richard Goddard, Tina Riedel, Paul J. Dyson, Vladimir N. Mikhaylov, Tatiyana V. Serebryanskaya, Viktor N. Sorokoumov, Matti Haukka|2018|Inorg.Chem.|57|930|doi:10.1021/acs.inorgchem.8b00072
CCDC 1577121: Experimental Crystal Structure Determination
2018
Related Article: Alexander G. Tskhovrebov, Anna A. Vasileva, Richard Goddard, Tina Riedel, Paul J. Dyson, Vladimir N. Mikhaylov, Tatiyana V. Serebryanskaya, Viktor N. Sorokoumov, Matti Haukka|2018|Inorg.Chem.|57|930|doi:10.1021/acs.inorgchem.8b00072