0000000001301387

AUTHOR

Erik Ekengard

showing 11 related works from this author

Thiophene based imino-pyridyl palladium(II) complexes : Synthesis, molecular structures and Heck coupling reactions

2017

Abstract The new compounds (5-methyl-2-thiophene-2-pyridyl(R))imine [R = methyl (L1); R = ethyl (L2)] and (5-bromo-2-thiophene-2-pyridyl(R)imine [R = methyl (L3); R = ethyl (L4)] were successfully synthesized via Schiff base condensation reaction and obtained in good yields. These potential ligands were reacted with [PdCl2(COD)] and [PdClMe(COD)] to give the corresponding complexes [PdCl2(L)] (L = L1-L4; 1–4) and [PdClMe(L)] (L = L1-L4; 5–8). All compounds were characterized by IR, 1H and 13C NMR spectroscopy, elemental analysis and mass spectrometry. The molecular structures of 1, 2, 6 and 8 were confirmed by X-ray crystallography. The complexes were evaluated as catalyst precursors for st…

Steric effectssynthesisStereochemistryIminechemistry.chemical_element010402 general chemistry01 natural sciencesBiochemistryMedicinal chemistryCatalysismolecular structuresInorganic Chemistrychemistry.chemical_compoundHeck reactionMaterials ChemistryThiophenePhysical and Theoretical Chemistryta116heck reactionsSchiff base010405 organic chemistryOrganic ChemistryCondensation reactionpalladium0104 chemical sciencesimino-pyridylchemistryPalladiumJournal of Organometallic Chemistry
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Pentamethylcyclopentadienyl-rhodium and iridium complexes containing (N^N and N^O) bound chloroquine analogue ligands: synthesis, characterization an…

2016

The synthesis and characterization of twenty new pentamethylcyclopentadienyl-rhodium and iridium complexes containing N^N and N^O-chelating chloroquine analogue ligands are described. The in vitro antimalarial activity of the new ligands as well as the complexes was evaluated against the chloroquine sensitive (CQS) NF54 and the chloroquine resistant (CQR) Dd2 strains of Plasmodium falciparum. The antimalarial activity was found to be good to moderate; although all complexes are less active than artesunate, some of the ligands and complexes showed better activity than chloroquine (CQ). In particular, rhodium complexes were found to be considerably more active than iridium complexes against t…

Models Molecularantimalarial propertiesStereochemistryPlasmodium falciparumDrug ResistanceMolecular Conformationchemistry.chemical_elementCrystal structureChemistry Techniques Synthetic010402 general chemistryIridiumLigands01 natural sciencesChlorideRhodiumIridium and Rhodium complexes chloroquine analog ligands Crystal structures in vitro antimalarian activityInorganic Chemistrychemistry.chemical_compoundAntimalarialsmedicineOrganometallic CompoundsMoietyRhodiumIridiumta116iridium complexesGroup 2 organometallic chemistrySchiff basechloroquine analogue ligands010405 organic chemistrypentamethylcyclopentadienyl-rhodium complexesChloroquine0104 chemical scienceschemistryDerivative (chemistry)medicine.drug
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Thiophene based imino-pyridyl palladium(II) complexes : Synthesis, molecular structures and Heck coupling reactions

2017

The new compounds (5-methyl-2-thiophene-2-pyridyl(R))imine [R = methyl (L1); R = ethyl (L2)] and (5-bromo-2-thiophene-2-pyridyl(R)imine [R = methyl (L3); R = ethyl (L4)] were successfully synthesized via Schiff base condensation reaction and obtained in good yields. These potential ligands were reacted with [PdCl2(COD)] and [PdClMe(COD)] to give the corresponding complexes [PdCl2(L)] (L = L1-L4; 1–4) and [PdClMe(L)] (L = L1-L4; 5–8). All compounds were characterized by IR, 1H and 13C NMR spectroscopy, elemental analysis and mass spectrometry. The molecular structures of 1, 2, 6 and 8 were confirmed by X-ray crystallography. The complexes were evaluated as catalyst precursors for standard He…

synteesipalladiumheck reactionsimino-pyridylmolecular structures
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CCDC 1426907: Experimental Crystal Structure Determination

2016

Related Article: Erik Ekengard, Kamlesh Kumar, Thibault Fogeron, Carmen de Kock, Peter J. Smith, Matti Haukka, Magda Monari, Ebbe Nordlander|2016|Dalton Trans.|45|3905|doi:10.1039/C5DT03739E

Space GroupCrystallographyCrystal System(eta5-pentamethylcyclopentadienyl)-(N-(7-chloroquinolin-4-yl)-N'-(pyridin-2-ylmethylene)ethane-12-diamine)-chloro-iridium(iii) chloride trihydrateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1525885: Experimental Crystal Structure Determination

2017

Related Article: Fatma M. Elantabli, Mduduzi P. Radebe, William M. Motswainyana, Bernard O. Owaga, Samir M. El-Medani, Erik Ekengard, Matti Haukka, Ebbe Nordlander, Martin O. Onani|2017|J.Organomet.Chem.|843|40|doi:10.1016/j.jorganchem.2017.04.022

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterschloro-methyl-(1-(5-methyl-2-thienyl)-N-(2-(pyridin-2-yl)ethyl)methanimine)-palladium(ii)Experimental 3D Coordinates
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CCDC 971206: Experimental Crystal Structure Determination

2017

Related Article: Fatma M. Elantabli, Mduduzi P. Radebe, William M. Motswainyana, Bernard O. Owaga, Samir M. El-Medani, Erik Ekengard, Matti Haukka, Ebbe Nordlander, Martin O. Onani|2017|J.Organomet.Chem.|843|40|doi:10.1016/j.jorganchem.2017.04.022

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterschloro-methyl-(1-(5-methyl-2-thienyl)-N-(2-(pyridin-2-yl)ethyl)methanimine)-palladium(ii)Experimental 3D Coordinates
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CCDC 1426908: Experimental Crystal Structure Determination

2016

Related Article: Erik Ekengard, Kamlesh Kumar, Thibault Fogeron, Carmen de Kock, Peter J. Smith, Matti Haukka, Magda Monari, Ebbe Nordlander|2016|Dalton Trans.|45|3905|doi:10.1039/C5DT03739E

Space GroupCrystallographyCrystal SystemCrystal Structure(eta5-pentamethylcyclopentadienyl)-(4-chloro-2-(((2-((7-chloroquinolin-4-yl)amino)ethyl)imino)methyl)phenolato)-chloro-rhodium(iii) dichloromethane solvateCell ParametersExperimental 3D Coordinates
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CCDC 971205: Experimental Crystal Structure Determination

2017

Related Article: Fatma M. Elantabli, Mduduzi P. Radebe, William M. Motswainyana, Bernard O. Owaga, Samir M. El-Medani, Erik Ekengard, Matti Haukka, Ebbe Nordlander, Martin O. Onani|2017|J.Organomet.Chem.|843|40|doi:10.1016/j.jorganchem.2017.04.022

Space GroupCrystallography(1-(5-bromo-2-thienyl)-N-(2-(pyridin-2-yl)ethyl)methanimine)-chloro-methyl-palladium(ii)Crystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1426906: Experimental Crystal Structure Determination

2016

Related Article: Erik Ekengard, Kamlesh Kumar, Thibault Fogeron, Carmen de Kock, Peter J. Smith, Matti Haukka, Magda Monari, Ebbe Nordlander|2016|Dalton Trans.|45|3905|doi:10.1039/C5DT03739E

(eta5-pentamethylcyclopentadienyl)-(N-(7-chloroquinolin-4-yl)-N'-(pyridin-2-ylmethyl)ethane-12-diamine)-chloro-rhodium(iii) chloride dichloromethane solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1510203: Experimental Crystal Structure Determination

2017

Related Article: Fatma M. Elantabli, Mduduzi P. Radebe, William M. Motswainyana, Bernard O. Owaga, Samir M. El-Medani, Erik Ekengard, Matti Haukka, Ebbe Nordlander, Martin O. Onani|2017|J.Organomet.Chem.|843|40|doi:10.1016/j.jorganchem.2017.04.022

Space GroupCrystallographydichloro-(1-(5-methyl-2-thienyl)-N-((pyridin-2-yl)methyl)methanimine)-palladium(ii) dichloromethane solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1510204: Experimental Crystal Structure Determination

2017

Related Article: Fatma M. Elantabli, Mduduzi P. Radebe, William M. Motswainyana, Bernard O. Owaga, Samir M. El-Medani, Erik Ekengard, Matti Haukka, Ebbe Nordlander, Martin O. Onani|2017|J.Organomet.Chem.|843|40|doi:10.1016/j.jorganchem.2017.04.022

Space GroupCrystallographydichloro-(1-(5-methyl-2-thienyl)-N-(2-(pyridin-2-yl)ethyl)methanimine)-palladium(ii)Crystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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