0000000001301903

AUTHOR

Dmitrijs Stepanovs

3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors

Abstract A new chemotype with carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action has been discovered, the homo-sulfocoumarins (3H-1,2-benzoxathiepine 2,2-dioxides) which have been designed considering the (sulfo)coumarins as lead molecules. An original synthetic strategy of a panel of such derivatives led to compounds with a unique inhibitory profile and very high selectivity for the inhibition of the tumour associated (CA IX/XII) over the cytosolic (CA I/II) isoforms. Although the CA inhibition mechanism with these new compounds is unknown for the moment, we hypothesize that it may be similar to that of the sulfocoumarins, i.e. hydrolysis to the corresponding sulfonic acids which therea…

research product

Crystallographic Study of Solvates and Solvate Hydrates of an Antibacterial Furazidin

In this study we present a detailed crystallographic analysis of multiple solvates of an antibacterial furazidin. Solvate formation of furazidin was investigated by crystallizing it from pure solvents and solvent-water mixtures. Crystal structure analysis of the obtained solvates and computational calculations were used to rationalize the main factors leading to the intermolecular interactions present in the solvate crystal structures as well as resulting in formation of the observed solvates and solvate hydrates. Furazidin forms pure solvates and solvate hydrates with solvents having large hydrogen bond acceptor propensity as well as with a hydrogen bond donor and acceptor formic acid. In …

research product

CCDC 2122147: Experimental Crystal Structure Determination

Related Article: Liāna Orola, Anatoly Mishnev, Dmitrijs Stepanovs, Agris Bērziņš|2022|ChemRxiv|||doi:10.26434/chemrxiv-2022-rb0xk

research product

CCDC 2121374: Experimental Crystal Structure Determination

Related Article: Liāna Orola, Anatoly Mishnev, Dmitrijs Stepanovs, Agris Bērziņš|2022|ChemRxiv|||doi:10.26434/chemrxiv-2022-rb0xk

research product

CCDC 2222725: Experimental Crystal Structure Determination

Related Article: Lia̅na Orola, Anatoly Mishnev, Dmitrijs Stepanovs, Agris Be̅rziņš|2022|Cryst.Growth Des.|23|873|doi:10.1021/acs.cgd.2c01114

research product

CCDC 2222724: Experimental Crystal Structure Determination

Related Article: Lia̅na Orola, Anatoly Mishnev, Dmitrijs Stepanovs, Agris Be̅rziņš|2022|Cryst.Growth Des.|23|873|doi:10.1021/acs.cgd.2c01114

research product

CCDC 2122145: Experimental Crystal Structure Determination

Related Article: Liāna Orola, Anatoly Mishnev, Dmitrijs Stepanovs, Agris Bērziņš|2022|ChemRxiv|||doi:10.26434/chemrxiv-2022-rb0xk

research product

CCDC 2122135: Experimental Crystal Structure Determination

Related Article: Liāna Orola, Anatoly Mishnev, Dmitrijs Stepanovs, Agris Bērziņš|2022|ChemRxiv|||doi:10.26434/chemrxiv-2022-rb0xk

research product

CCDC 1526002: Experimental Crystal Structure Determination

Related Article: Aleksandrs Pustenko, Dmitrijs Stepanovs, Raivis Žalubovskis, Daniela Vullo, Andris Kazaks, Janis Leitans, Kaspars Tars, Claudiu T. Supuran|2017|J.Enzyme Inhib.Med.Chem.|32|767|doi:10.1080/14756366.2017.1316720

research product

CCDC 2122164: Experimental Crystal Structure Determination

Related Article: Liāna Orola, Anatoly Mishnev, Dmitrijs Stepanovs, Agris Bērziņš|2022|ChemRxiv|||doi:10.26434/chemrxiv-2022-rb0xk

research product

CCDC 928882: Experimental Crystal Structure Determination

Related Article: Liāna Orola, Anatoly Mishnev, Dmitrijs Stepanovs, Agris Bērziņš|2022|ChemRxiv|||doi:10.26434/chemrxiv-2022-rb0xk

research product

CCDC 922708: Experimental Crystal Structure Determination

Related Article: Liāna Orola, Anatoly Mishnev, Dmitrijs Stepanovs, Agris Bērziņš|2022|ChemRxiv|||doi:10.26434/chemrxiv-2022-rb0xk

research product

CCDC 2122176: Experimental Crystal Structure Determination

Related Article: Liāna Orola, Anatoly Mishnev, Dmitrijs Stepanovs, Agris Bērziņš|2022|ChemRxiv|||doi:10.26434/chemrxiv-2022-rb0xk

research product

CCDC 922164: Experimental Crystal Structure Determination

Related Article: Liāna Orola, Anatoly Mishnev, Dmitrijs Stepanovs, Agris Bērziņš|2022|ChemRxiv|||doi:10.26434/chemrxiv-2022-rb0xk

research product

CCDC 2222740: Experimental Crystal Structure Determination

Related Article: Lia̅na Orola, Anatoly Mishnev, Dmitrijs Stepanovs, Agris Be̅rziņš|2022|Cryst.Growth Des.|23|873|doi:10.1021/acs.cgd.2c01114

research product

CCDC 2121392: Experimental Crystal Structure Determination

Related Article: Liāna Orola, Anatoly Mishnev, Dmitrijs Stepanovs, Agris Bērziņš|2022|ChemRxiv|||doi:10.26434/chemrxiv-2022-rb0xk

research product