0000000001301964

AUTHOR

Simone D’agostino

showing 12 related works from this author

ATTIVITA’ CITOTOSSICA DI COMPLESSI ORGANOSTAGNO(IV) CON TRIAZOLOPIRIMIDINE CONTENENTI ATOMI DI OSSIGENO ESOCICLICO

2019

Le triazolopirimidine sono leganti eterociclici di crescente interesse. I composti di organostagno(IV) sono caratterizzati dalla presenza di un atomo di stagno (Sn) legato covalentemente ad uno o più sostituenti organici. In questo studio1 sono stati sintetizzati: Me3Sn(5tpO)(1); n-Bu3Sn(5tpO)(2); Me3Sn(mtpO)(3); n-Bu3Sn(mtpO)(4); n-Bu3Sn(HtpO2)(5); Ph3Sn(HtpO2)(6) e la loro citotossicità valutata su tre differenti linee cellulari tumorali umane: HCT-116 (carcinoma del colon retto), HepG2 (epatocarcinoma) e MCF-7 (carcinoma mammario). I complessi 2, 4, 5 e 6 hanno mostrato attività citotossica di 1-2 ordini di grandezza superiore al cis-platino, sulle 3 linee cellulari tumorali. Il meccanis…

triazolopirimidine attività citotossica
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CCDC 1908619: Experimental Crystal Structure Determination

2020

Related Article: Alessandro Attanzio, Simone D’Agostino, Rosalia Busà, Anna Frazzitta, Simona Rubino, Maria Assunta Girasolo, Piera Sabatino, Luisa Tesoriere|2020|Molecules|25|859|doi:10.3390/molecules25040859

Space GroupCrystallographycatena-[(mu-5-oxo-5H-[124]triazolo[15-a]pyrimidin-3-ido)-tributyl-tin]Crystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1569159: Experimental Crystal Structure Determination

2017

Related Article: Toms Rekis, Simone d’Agostino, Dario Braga, Fabrizia Grepioni|2017|Cryst.Growth Des.|17|6477|doi:10.1021/acs.cgd.7b01146

Space GroupCrystallography2-(1-azabicyclo[2.2.2]octan-3-yl)-1H-benzo[de]isoquinoline-13(2H)-dioneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1569164: Experimental Crystal Structure Determination

2017

Related Article: Toms Rekis, Simone d’Agostino, Dario Braga, Fabrizia Grepioni|2017|Cryst.Growth Des.|17|6477|doi:10.1021/acs.cgd.7b01146

2-(1-azabicyclo[2.2.2]octan-3-yl)-6-(piperidin-1-yl)-1H-benzo[de]isoquinoline-13(2H)-dioneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1569163: Experimental Crystal Structure Determination

2017

Related Article: Toms Rekis, Simone d’Agostino, Dario Braga, Fabrizia Grepioni|2017|Cryst.Growth Des.|17|6477|doi:10.1021/acs.cgd.7b01146

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersrac-2-(1-azabicyclo[2.2.2]octan-3-yl)-6-(piperidin-1-yl)-1H-benzo[de]isoquinoline-13(2H)-dioneExperimental 3D Coordinates
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CCDC 1569161: Experimental Crystal Structure Determination

2017

Related Article: Toms Rekis, Simone d’Agostino, Dario Braga, Fabrizia Grepioni|2017|Cryst.Growth Des.|17|6477|doi:10.1021/acs.cgd.7b01146

Space GroupCrystallography2-(1-azabicyclo[2.2.2]octan-3-yl)-1H-benzo[de]isoquinoline-13(2H)-dioneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 1569160: Experimental Crystal Structure Determination

2017

Related Article: Toms Rekis, Simone d’Agostino, Dario Braga, Fabrizia Grepioni|2017|Cryst.Growth Des.|17|6477|doi:10.1021/acs.cgd.7b01146

Space GroupCrystallography2-(1-azabicyclo[2.2.2]octan-3-yl)-1H-benzo[de]isoquinoline-13(2H)-dioneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 1569165: Experimental Crystal Structure Determination

2017

Related Article: Toms Rekis, Simone d’Agostino, Dario Braga, Fabrizia Grepioni|2017|Cryst.Growth Des.|17|6477|doi:10.1021/acs.cgd.7b01146

2-(1-azabicyclo[2.2.2]octan-3-yl)-6-(piperidin-1-yl)-1H-benzo[de]isoquinoline-13(2H)-dioneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1908620: Experimental Crystal Structure Determination

2020

Related Article: Alessandro Attanzio, Simone D’Agostino, Rosalia Busà, Anna Frazzitta, Simona Rubino, Maria Assunta Girasolo, Piera Sabatino, Luisa Tesoriere|2020|Molecules|25|859|doi:10.3390/molecules25040859

Space GroupCrystallographycatena-[(mu-5-oxo-5H-[124]triazolo[15-a]pyrimidin-3-ido)-trimethyl-tin]Crystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1569157: Experimental Crystal Structure Determination

2017

Related Article: Toms Rekis, Simone d’Agostino, Dario Braga, Fabrizia Grepioni|2017|Cryst.Growth Des.|17|6477|doi:10.1021/acs.cgd.7b01146

Space GroupCrystallography2-(1-azabicyclo[2.2.2]octan-3-yl)-1H-benzo[de]isoquinoline-13(2H)-dioneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 1569158: Experimental Crystal Structure Determination

2017

Related Article: Toms Rekis, Simone d’Agostino, Dario Braga, Fabrizia Grepioni|2017|Cryst.Growth Des.|17|6477|doi:10.1021/acs.cgd.7b01146

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersrac-2-(1-azabicyclo[2.2.2]octan-3-yl)-1H-benzo[de]isoquinoline-13(2H)-dioneExperimental 3D Coordinates
researchProduct

CCDC 1569162: Experimental Crystal Structure Determination

2017

Related Article: Toms Rekis, Simone d’Agostino, Dario Braga, Fabrizia Grepioni|2017|Cryst.Growth Des.|17|6477|doi:10.1021/acs.cgd.7b01146

2-(1-azabicyclo[2.2.2]octan-3-yl)-6-(piperidin-1-yl)-1H-benzo[de]isoquinoline-13(2H)-dioneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct