0000000001302328

AUTHOR

Maria Michela Dell'anna

showing 4 related works from this author

DNA-binding and in vitro cytotoxic activity of platinum(II) complexes of curcumin and caffeine

2019

Abstract Three Pt(II) complexes containing the natural ligands curcumin and caffeine, namely [Pt(curc)(PPh3)2]Cl (1), [PtCl(curc)(DMSO)] (2) (curc = deprotonated curcumin) and trans-[Pt(caffeine)Cl2(DMSO)] (3), were synthesized and fully characterized. The data obtained suggest that, for both 1 and 2, the anion of curcumin is coordinated to the platinum ion via the oxygen atoms of the β-diketonate moiety. Spectroscopic features reveal that in 2 and 3, a DMSO molecule is S-bonded to the metal centre. For 3, all data indicate a square-planar geometry formed by a 9-N bonded caffeine, two trans chloride anions and a DMSO. The three complexes undergo changes in solution upon incubation for 24 h;…

PhotoactivationCurcuminCytotoxicityIntercalation (chemistry)chemistry.chemical_elementCaffeine; Curcumin; Cytotoxicity; DNA interaction; Natural ligands; Photoactivation; Platinum(II) complexAntineoplastic Agents010402 general chemistryLigands01 natural sciencesBiochemistryMedicinal chemistryNucleobaseInorganic Chemistrychemistry.chemical_compoundDrug StabilityCoordination ComplexesCaffeineCell Line TumorMoietyMoleculeAnimalsHumansPlatinumMolecular Structure010405 organic chemistryDNA0104 chemical sciencesDNA interactionchemistryCurcuminPlatinum(II) complexCattleCaffeine Curcumin Cytotoxicity DNA interaction Natural ligands Photoactivation Platinum(II) complexCisplatinDrug Screening Assays AntitumorSelectivityPlatinumNatural ligandsCis–trans isomerism
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Triphenylphosphane Pt(II) complexes containing biologically active natural polyphenols: Synthesis, crystal structure, molecular modeling and cytotoxi…

2016

Platinum complexes bearing phosphane ligands in cis configuration with deprotonated flavonoids (3-hydroxyflavone, quercetin) and deprotonated ethyl gallate were synthesized starting from cis-[PtCl2(PPh3)(2)]. In all cases, O,O' chelate structures were obtained. While quercetin and ethyl gallate complexes are quite stable in solution, the 3-hydroxyflavonate complex undergoes a slow aerobic photodegradation in solution with formation of salicylic and benzoic acids. The X-ray diffraction structures of quercetin and ethyl gallate complexes are reported. Cell cycle studies (in the dark) of the complexes in two human cell lines revealed that the cytotoxic activity of the complex bearing 3-hydroxy…

Models MolecularPlatinum(II) complexesOrganoplatinum CompoundsMolecular modelStereochemistryPlatinum(II) complexes; Cytotoxic activity; Natural polyphenols; Flavonoids; DFTEthyl gallateCrystal structureCytotoxic activity; DFT; Flavonoids; Natural polyphenols; Platinum(II) complexesCrystallography X-Ray010402 general chemistry01 natural sciencesBiochemistryMedicinal chemistryDFTInorganic ChemistryHydrolysischemistry.chemical_compoundDeprotonationHumansChelationPhotodegradationCytotoxic activity DFT Flavonoids Natural polyphenols Platinum(II) complexesFlavonoidsCytotoxic activityCytotoxins010405 organic chemistryChemistryPolyphenols0104 chemical sciencesMCF-7 CellsNatural polyphenolsCis–trans isomerism
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CCDC 1430059: Experimental Crystal Structure Determination

2016

Related Article: Maria Michela Dell'Anna, Valentina Censi, Benedetta Carrozzini, Rocco Caliandro, Nunzio Denora, Massimo Franco, Daniele Veclani, Andrea Melchior, Marilena Tolazzi, Piero Mastrorilli|2016|J.Inorg.Biochem.|163|346|doi:10.1016/j.jinorgbio.2016.08.006

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterscis-(4-(357-trihydroxy-4-oxo-4H-1-benzopyran-2-yl)benzene-12-bisolato)-bis(triphenylphosphine)-platinum(ii)Experimental 3D Coordinates
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CCDC 1430058: Experimental Crystal Structure Determination

2016

Related Article: Maria Michela Dell'Anna, Valentina Censi, Benedetta Carrozzini, Rocco Caliandro, Nunzio Denora, Massimo Franco, Daniele Veclani, Andrea Melchior, Marilena Tolazzi, Piero Mastrorilli|2016|J.Inorg.Biochem.|163|346|doi:10.1016/j.jinorgbio.2016.08.006

Space GroupCrystallographycis-(5-(ethoxycarbonyl)-3-hydroxybenzene-12-bis(olato))-bis(triphenylphosphine)-platinum(ii)Crystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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