Author: Ehsan Sheikhi

0000000001302733

AUTHOR

Ehsan Sheikhi

Enantioselective addition of sodium bisulfite to nitroalkenes. A convenient approach to chiral sulfonic acids

An enantioselective organocatalytic addition of sodium bisulfite to (E)-nitroalkenes has been developed by using a chiral bifunctional organocatalyst. The present methodology provides a variety of chiral β-nitroethanesulfonic acid compounds (17 examples) with excellent results: up to 99% yield and excellent enantioselectivity (up to 96% ee). The reaction tolerates (hetero)aryl and alkyl substituents on the β-nitroalkenes, and β,β-disubstituted nitroalkenes.

research product

CCDC 2098671: Experimental Crystal Structure Determination

Related Article: Ehsan Sheikhi, Narjes Rezaei, Alvaro Castilla, Amparo Sanz��Marco, Carlos Vila, M. Carmen Mu��oz, Jos�� R. Pedro, Gonzalo Blay|2021|Eur.J.Org.Chem.|2021|5284|doi:10.1002/ejoc.202101064

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