Author: Frederic Boschetti

0000000001302947

AUTHOR

Frederic Boschetti

showing 11 related works from this author

Reaction of polyamines with diethyloxalate: a convenient route for the synthesis of tetraazacycloalkanes

2006

International audience; The reactivity of various polyamines with diethyloxalate has been investigated. It appears that, in similar experimental conditions, primary diamines give predominantly [2+2] adducts while the use of secondary benzylated polyamines results in [1+1] condensation. Although the intermediate tetraamides formed in the first case are extremely poorly soluble and show very slow reactivity towards reducing agents, cyclam has been obtained by using ultrasounds during the reaction of the corresponding tetraoxomacrocycle with BH 3 /THF. The [1+1] cyclization reaction of diversely N-benzylated linear tetraamines, whose selective syntheses have been devised herein, gives access t…

synthesisReducing agent010402 general chemistry01 natural sciencesAdductlcsh:QD241-441chemistry.chemical_compoundlcsh:Organic chemistry[PHYS.COND.CM-GEN] Physics [physics]/Condensed Matter [cond-mat]/Other [cond-mat.other][ CHIM.ORGA ] Chemical Sciences/Organic chemistryAmideCyclamOrganic chemistryReactivity (chemistry)ComputingMilieux_MISCELLANEOUSPrimary (chemistry)010405 organic chemistryChemistry[CHIM.ORGA]Chemical Sciences/Organic chemistrytetraaminesOrganic ChemistryCombinatorial chemistry0104 chemical sciences[PHYS.COND.CM-GEN]Physics [physics]/Condensed Matter [cond-mat]/Other [cond-mat.other]AminalAmine gas treating

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The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy

2014

International audience; A new efficient type of gadolinium-based theranostic agent (AGuIX) has recently been developed for magnetic resonance imaging (MRI)-guided radiotherapy. These new particles consist of a polysiloxane network surrounded by a number of gadolinium chelates, usually 10. Due to their small size (<5 nm), AGuIX typically exhibit biodistributions that are almost ideal for diagnostic and therapeutic purposes. For example, while a significant proportion of these particles accumulate in tumours, the remainder is rapidly eliminated by the renal route. In addition, these particles present no evidence of toxicity, in the absence of irradiation with up to 10 times the planned dose f…

Radiation-Sensitizing Agentsmedicine.medical_treatmentGadoliniumContrast MediaGadoliniumReview Article02 engineering and technologyQUANTUM DOTSIonizing radiation[ SDV.CAN ] Life Sciences [q-bio]/CancerMicechemistry.chemical_compound0302 clinical medicineNuclear magnetic resonanceNeoplasmsIN-VIVOmedicine.diagnostic_testNEUTRON-CAPTURE THERAPYGeneral Medicine021001 nanoscience & nanotechnologyMagnetic Resonance Imaging3. Good health030220 oncology & carcinogenesis/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being0210 nano-technologyMRIMaterials scienceRadiotherapy and OncologySiloxanesMOTEXAFIN GADOLINIUMchemistry.chemical_element[SDV.CAN]Life Sciences [q-bio]/Cancer03 medical and health sciences[SDV.CAN] Life Sciences [q-bio]/CancerSDG 3 - Good Health and Well-beingIn vivoRADIATION-THERAPYmedicineAnimalsHumansBREAST-CANCERRadiology Nuclear Medicine and imagingIrradiationbusiness.industryMagnetic resonance imagingModels TheoreticalRadiation therapychemistryMotexafin gadoliniumGOLD NANOPARTICLESNanoparticlesParticleCONTRAST AGENTSIONIZING-RADIATIONNuclear medicinebusiness

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Functionalization of ultrasmall nanoparticles for theranosctic applications

2015

International audience

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AGuIX modifications for active tumor targeting and radiolabelling

2014

International audience

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Radiolabeling for long term biodistribution of ultrasmall nanoparticles designed for radiotherapy guided by MRI

2016

International audience

[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging[SDV.CAN]Life Sciences [q-bio]/Cancer[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciencesFunctionalisation89ZrImaging[SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/ImagingPETNanoparticle[SDV.CAN] Life Sciences [q-bio]/CancerTheranosticSPECT[CHIM] Chemical Sciences[CHIM]Chemical SciencesComputingMilieux_MISCELLANEOUSCancerMRI

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