Regulación de la obtención de muestras procedentes de cadáveres

Performance of a Highly Sensitive Mycobacterium tuberculosis Complex Real-Time PCR Assay for Diagnosis of Pulmonary Tuberculosis in a Low-Prevalence Setting: a Prospective Intervention Study

ABSTRACT The potential impact of routine real-time PCR testing of respiratory specimens from patients with presumptive tuberculosis in terms of diagnostic accuracy and time to tuberculosis treatment inception in low-prevalence settings remains largely unexplored. We conducted a prospective intervention cohort study. Respiratory specimens from 1,020 patients were examined by acid-fast bacillus smear microscopy, tested by a real-time Mycobacterium tuberculosis complex PCR assay (Abbott RealTi me MTB PCR), and cultured in mycobacterial media. Seventeen patients tested positive by PCR (5 were acid-fast bacillus smear positive and 12 acid-fast bacillus smear negative), and Mycobacterium tubercul…

Early detection of Toxoplasma infection by molecular monitoring of Toxoplasma gondii in peripheral blood samples after allogeneic stem cell transplantation

International audience; Background. Isolated case reports have shown that recipients of allogeneic hematopoietic stem cell transplants ( HSCTs) who develop toxoplasmosis may have circulating Toxoplasma gondii DNA in peripheral blood before the onset of clinical symptoms. Methods. We prospectively studied 106 T. gondii - seropositive adult recipients of HSCTs for the incidence of reactivation of toxoplasmosis in the first 6 months after transplantation. Toxoplasmosis infection ( TI) was defined by a positive result of polymerase chain reaction ( PCR) of peripheral blood specimens, whereas toxoplasmosis disease ( TD) was defined as an invasive infection. Results. The incidence of TI was 16% (…

Design of ordered bimetallic complexes, Part 2:Trans-1,2-cyclohexanediaminetetraacetate bimetallates

Knowledge of the kinetic and thermodynamic behaviour of aqueous solutions containing two divalent cations andtrans-1,2-cyclohexanediaminetetraacetate has been used to design synthetic pathways to ordered bimetallic complexes

Synthesis, spectroscopic characterization and electrochemical behaviour of nickel(II) complexes with C-meso-5,5,7,12,12,14-hexamethylcyclotetradecane (Me6[14]aneN4). Crystal structure of {Ni(Me6[14]aneN4)|I2

A series of complexes of formula {Ni(Me6[14]aneN4)X2| (Me6[14]aneN4) = C-meso-5,5,7,12,12,14-hexamethyl-1,4,-8,11-tetraazacyclotetradecane and X = N3(1), NCO (2), NCS (3), AcO (4) or I (5) has been synthesized. The crystal structure of (5) has been determined by X-ray diffraction methods. The nickel atom is surrounded by a square-planar array of nitrogen atoms, giving a low-spin complex. The macrocyclic ligand shows the most stable conformation, the six-membered rings exhibiting the chair form while the gauche conformation is adopted by the five-membered rings. Spectroscopic and magnetic data for (1)–(4) are consistent with octahedral coordination around the nickel atom, which is achieved b…

CCDC 1417214: Experimental Crystal Structure Determination

Related Article: Tania Romero-Morcillo, Maksym Seredyuk, Carmen Muñoz, Jose A. Real|2015|Angew.Chem.,Int.Ed.|54|14777|doi:10.1002/anie.201507620

CCDC 1417215: Experimental Crystal Structure Determination

Related Article: Tania Romero-Morcillo, Maksym Seredyuk, Carmen Muñoz, Jose A. Real|2015|Angew.Chem.,Int.Ed.|54|14777|doi:10.1002/anie.201507620

CCDC 1417216: Experimental Crystal Structure Determination

Related Article: Tania Romero-Morcillo, Maksym Seredyuk, Carmen Muñoz, Jose A. Real|2015|Angew.Chem.,Int.Ed.|54|14777|doi:10.1002/anie.201507620