Author: Zofia Lazar

0000000001303994

AUTHOR

Zofia Lazar

Synthesis, structure, properties and antimicrobial activity of para trifluoromethyl phenylboronic derivatives

The [2-formyl-4-(trifluoromethyl)phenyl]boronic acid as well as its benzoxaborole and bis(benzoxaborole) derivatives were obtained and their properties studied. The 2-formyl compound displays an unusual structure in the crystalline state, with a significant twist of the boronic group, whereas in DMSO solution it tautomerizes with formation of a cyclic isomer. All the studied compounds exhibit relatively high acidity as well as a reasonable antimicrobial activity. Docking studies showed interactions of all the investigated compounds with the binding pocket of Candida albicans LeuRS. High activity against Bacillus cereus was determined for the 2-formyl compound as well as for the novel bis(be…

research product

CCDC 2082738: Experimental Crystal Structure Determination

Related Article: Agnieszka Adamczyk-Wo��niak, Magdalena Tarkowska, Zofia Lazar, Ewa Kaczorowska, Izabela D. Madura, Anna Maria D��browska, Jacek Lipok, Dorota Wieczorek|2021|Bioorg.Chem.|119|105560|doi:10.1016/j.bioorg.2021.105560

research product

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
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  - PE2_3Experimental particle physics with accelerators
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  - PE2_10Atomic, molecular physics
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  - PE2_18Equilibrium and non-equilibrium statistical mechanics: steady states and dynamics
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  - PE2_13Quantum optics and quantum information
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- PE1Mathematics
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  - PE11_12Semi-conducting and magnetic materials engineering
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LSLife Sciences
- LS1Molecules of Life: Biological Mechanisms, Structures and Functions
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SHSocial Sciences and Humanities
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