The rxr agonist bexarotene in combination with rosuvastatin inhibits angiotensin-ii induced abdominal aortic aneurysm formation in apoliprotein -e-knockout mice

Measurement of CP asymmetry in Bs0 → Ds ∓K± decays

Journal of high energy physics 2018(3), 59 (2018). doi:10.1007/JHEP03(2018)059

Assessing behavioural problems and assets in children and adolescents

Abstract The main purpose of this brief report is to introduce a wide range battery of instruments for the psychological assessment of children and adolescents, which was developed in Spain and coordinated by the last author. The battery includes a General Diagnostic Report (anamnesis and general way of life), two Behaviour Problem Scales (one for school and one for non-school settings), a Hyperactivity Scale, the ‘Battery of Socialization’, the I-6 (Junior) Questionnaire, the EPQ-J, a Questionnaire for the Assessment of Self-Concept, the Antisocial Behaviour Scale, a Locus of Control Scale, an Irrational Beliefs Inventory, an Assertiveness Scale, a Fear Inventory, an Anxiety Scale, a Depre…

Inductively coupled plasma atomic emission spectrometric determination of arsenic in mussel products

A precise, accurate procedure is proposed for the determination of arsenic in mussel products by inductively coupled plasma atomic emission spectrometry. Organic matter is destroyed by dry ashing. Experimental conditions for the determination of arsenic were selected and an interference study was carried out. The methodology developed has a detection limit of 0.1 μg g−1, a relative standard deviation of 3%, and a recovery percentage of 98±2%. The accuracy of the method was checked by analysis of a certified sample of NIST oyster tissue (certified 14.0±1.2 μg g−1; found 14.1±1.1 μg g−1). The proposed procedure was used to analyze real samples of mussel products.

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…

Human Immunodeficiency Virus Continuum of Care in 11 European Union Countries at the End of 2016 Overall and by Key Population: Have We Made Progress?

Abstract Background High uptake of antiretroviral treatment (ART) is essential to reduce human immunodeficiency virus (HIV) transmission and related mortality; however, gaps in care exist. We aimed to construct the continuum of HIV care (CoC) in 2016 in 11 European Union (EU) countries, overall and by key population and sex. To estimate progress toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 target, we compared 2016 to 2013 estimates for the same countries, representing 73% of the population in the region. Methods A CoC with the following 4 stages was constructed: number of people living with HIV (PLHIV); proportion of PLHIV diagnosed; proportion of those diagnosed …

The large trans-Neptunian object 2002 TC 302 from combined stellar occultation, photometry, and astrometry data

All authors: Ortiz, J. L.; Santos-Sanz, P.; Sicardy, B.; Benedetti-Rossi, G.; Duffard, R.; Morales, N.; Braga-Ribas, F.; Fernández-Valenzuela, E.; Nascimbeni, V.; Nardiello, D.; Carbognani, A.; Buzzi, L.; Aletti, A.; Bacci, P.; Maestripieri, M.; Mazzei, L.; Mikuz, H.; Skvarc, J.; Ciabattari, F.; Lavalade, F. Scarfi, G.; Mari, J. M.; Conjat, M.; Sposetti, S.; Bachini, M.; Succi, G.; Mancini, F.; Alighieri, M.; Dal Canto, E.; Masucci, M.; Vara-Lubiano, M.; Gutiérrez, P. J.; Desmars, J.; Lecacheux, J.; Vieira-Martins, R.; Camargo, J. I. B.; Assafin, M.; Colas, F.; Beisker, W.; Behrend, R.; Mueller, T. G.; Meza, E.; Gomes-Junior, A. R.; Roques, F.; Vachier, F.; Mottola, S.; Hellmich, S.; Campo …

Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages

Summary Background Oxidative stress is present in airway diseases such as severe asthma or Chronic Obstructive Pulmonary Disease and contributes to the low response to glucocorticoids through the down-regulation of histone deacetylase (HDAC) activity. Objective To study the effects of the phosphodiesterase (PDE)-3 and 4 inhibitors and their combination vs. glucocorticoids in a model of lipopolysaccharide (LPS)-induced cytokine release in alveolar macrophages under oxidative stress conditions. Methods Differentiated U937 or human alveolar macrophages were stimulated with H2O2 (10–1000 μm) or cigarette smoke extract (CSE, 0–15%) for 4 h before LPS (0.5 μg/mL, 24 h) addition. In other experime…

Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohort study

The outbreak of severe acute respiratory syndromecoronavirus-2, the cause of coronavirus disease 2019 (COVID-19) in December 2019 represented a global emergency accounting for more than 2.5 million deaths worldwide.1 It has had an unprecedented influence on cardiac surgery internationally, resulting in cautious delivery of surgery and restructuring of services.2 Understanding the influence of COVID-19 on patients after cardiac surgery is based on assumptions from other surgical specialties and single-center studies. The COVIDSurg Collaborative conducted a multicenter cohort study, including 1128 patients, across 235 hospitals, from 24 countries demonstrating perioperative COVID-19 infection…

Synergistic antiangiogenic activity of bexarotene in combination with rosuvastatin by targeting ang-ii-mediated akt/mtor/p70s6k signaling pathway

Combined treatment with bexarotene and rosuvastatin reduces angiotensin-II-induced abdominal aortic aneurysm in apoE−/−mice and angiogenesis

Background and Purpose Abdominal aortic aneurysm (AAA) is a degenerative vascular disease associated with angiogenesis. Bexarotene is a retinoid X receptor (RXR) ligand with anti-angiogenic activity. Statins also exert anti-angiogenic activity and activate PPARs. Because RXR ligands form permissive heterodimers with PPARs and a single anti-angiogenic drug may not be sufficient to combat the wide array of angiogenic factors produced during AAA, we evaluated the effect of combined low doses of bexarotene and rosuvastatin in a mouse model of AAA.

Searches for violation of lepton flavour and baryon number in tau lepton decays at LHCb

Searches for the lepton flavour violating decay tau(-) -> mu(-)mu(+)mu(-) and the lepton flavour and baryon number violating decays tau(-) -> (p) over bar mu(+)mu(-) and tau(-) -> p mu(-)mu(-) have been carried out using proton-proton collision data, corresponding to an integrated luminosity of 1.0 fb(-1), taken by the LHCb experiment at root s = 7 TeV. No evidence has been found for any signal, and limits have been set at 90% confidence level on the branching fractions: B(tau(-) -> mu(-)mu(+)mu(-) mu(+)mu(-)) p mu(-)mu(-)) (p) over bar mu(+)mu(-) and tau(-) -> p mu(-)mu(-) decay modes represent the first direct experimental limits on these channels.

Combination of finite impulse response neural network technique with FDTD method for simulation of electromagnetic problems

The finite difference time domain (FDTD) method requires long computation times for simulating resonant or high-Q structures. The authors incorporate the finite impulse response neural network technique as a predictor in order to save time in FDTD simulations. The applicability of the technique is demonstrated by carrying out an analysis of a waveguide filter.

Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score

The British journal of surgery 108(11), 1274-1292 (2021). doi:10.1093/bjs/znab183

CCDC 192867: Experimental Crystal Structure Determination

Related Article: S.Fustero, B.Pina, E.Salavert, A.Navarro, M.C.R.de Arellano, A.S.Fuentes|2002|J.Org.Chem.|67|4667|doi:10.1021/jo025621k

CCDC 192866: Experimental Crystal Structure Determination

Related Article: S.Fustero, B.Pina, E.Salavert, A.Navarro, M.C.R.de Arellano, A.S.Fuentes|2002|J.Org.Chem.|67|4667|doi:10.1021/jo025621k

The large TNO 2002 TC302

VizieR online Data Catalogue associated with article published in journal Astronomy & Astrophysics with title 'The large Trans-Neptunian object 2002 TC302 from combined stellar occultation photometry and astrometry data.' (bibcode: 2020A&A...639A.134O)