0000000001305295
AUTHOR
Lauri Happonen
Foldameerien isäntä-vieraskemia
Tutkielman kirjallisessa osassa tarkastellaan foldameerejä isäntä-vieraskemian näkökulmasta. Foldameerit voivat sitoa rakenteeseensa erilaisia vierasmolekyylejä, jolloin muodostuu isäntä-vieraskomplekseja. Kirjallisuudesta valittiin tarkasteluun mielenkiintoisimpia anioneja, kationeja ja neutraaleja vierasmolekyylejä sitovia foldameereja ja perehdyttiin niiden vuorovaikutuksiin. Lisäksi tarkasteltiin vierasmolekyylin sitoutumisen aikaansaamia muutoksia foldameerien konformaatiossa. Kokeellisen osan tarkoituksena oli syntetisoida pitkä, 11 aromaattista rengasta sisältävä aryyliamidifoldameeri käyttäen hyväksi pääasiassa peptidikytkentäreaktioita. Koska synteesi osoittautui erittäin haasteell…
Thiourea Based Tritopic Halogen Bonding Acceptors
Series of thiourea based tritopic receptor molecules were synthesized to be used as building blocks for halogen-bonded assemblies. Here 16 new receptor molecules were synthesized from two different 2,4,6-trialkyl-1,3,5-tris(bromomethyl)benzene starting materials via tris(isothiocyanatomethyl)benzene intermediates. The alkyl substituents in the benzene ring showed to be important for isothiocyanate group formation instead of competing thiocyanate group. The synthesis route allowed us to synthesize the isothiocyanate intermediates and further the receptor molecules without typically used and highly toxic thiophosgene. Synthesized receptor molecules were used to study their halogen bond accept…
Halogen Bonding between Thiocarbonyl Compounds and 1,2- and 1,4-Diiodotetrafluorobenzenes
The halogen bonding (XB) between 1,2-diiodotetrafluorobenzene (1,2-DITFB) or 1,4-diiodotetrafluorobenzene (1,4-DITFB) and the selection of different thiocarbonyl acceptors was studied by the single-crystal X-ray diffraction method. Diiodotetrafluorobenzenes (DITFBs) were found to form C-I···S halogen-bonded 1:1, 2:1, and 1:2 (donor/acceptor ratio) complexes with thiocarbonyls. Lengths of contacts were found to be clearly shorter than the sum of van der Waals radii of iodine and sulfur as well as the contact angles showed values close to linear, so the XB interactions could be verified. One sulfur atom showed the ability to accept one, two, or four XB interactions, and the acceptor angle can…
CCDC 2061197: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061192: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061203: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061184: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061201: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061186: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061190: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061198: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061193: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061199: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061194: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061185: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061204: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061196: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061189: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061191: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061195: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061188: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061202: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061187: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183
CCDC 2061200: Experimental Crystal Structure Determination
Related Article: Lauri Happonen, J. Mikko Rautiainen, Arto Valkonen|2021|Cryst.Growth Des.|21|3409|doi:10.1021/acs.cgd.1c00183