Author: Claudia Schmidt

0000000001305302

AUTHOR

Claudia Schmidt

showing 13 related works from this author

"Dynamical Docking" of Cyclic Dinuclear Au(I) Bis-N-heterocyclic Complexes Facilitates Their Binding to G-Quadruplexes.

2022

With the aim to improve the design of metal complexes as stabilizers of noncanonical DNA secondary structures, namely, G-quadruplexes (G4s), a series of cyclic dinuclear Au(I) N-heterocyclic carbene complexes based on xanthine and benzimidazole ligands has been synthesized and characterized by various methods, including X-ray diffraction. Fluorescence resonance energy transfer (FRET) and CD DNA melting assays unraveled the compounds’ stabilization properties toward G4s of different topologies of physiological relevance. Initial structure–activity relationships have been identified and recognize the family of xanthine derivatives as those more selective toward G4s versus duplex DNA. The bind…

Inorganic ChemistryG-quadruplexPhysical and Theoretical ChemistryInorganic chemistry

researchProduct

Highly-fluorescent BODIPY-functionalised metallacages as drug delivery systems

2022

With the aim of designing new metallosupramolecular architectures for drug delivery, research has focused on porous 3-dimensional (3D)-metallacages able to encapsulate cytotoxic agents protecting them from metabolism while targeting them to cancer sites. Here, two self-assembled [Pd2L4]4+ cages (CG1 and CG2) featuring 3,5-bis(3-ethynylpyridine)phenyl ligands (L) exo-functionalised with dipyrromethene (BODIPY) groups have been synthesised and characterised by different methods, including NMR spectroscopy and mass spectrometry. 1H NMR spectroscopy studies shows that the cages are able to encapsulate the anticancer drug cisplatin in their hydrophobic cavity, as evidenced by electrostatic poten…

Boron CompoundsInorganic ChemistryDrug Delivery SystemsCell Line TumorHumansCisplatinPalladiumDalton Transactions

researchProduct

The Barrett‐associated variants at GDF 7 and TBX 5 also increase esophageal adenocarcinoma risk

2016

Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) represent two stages within the esophagitis-metaplasia-dysplasia-adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE/EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes GDF7 (rs3072), TBX5 (rs2701108), and ALDH1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE/EAC sequence. Our data show that rs3072 at GDF7 and rs2701108 at TBX5 are also associated with EAC and …

0301 basic medicineCancer ResearchCase-control studyGenome-wide association studyLocus (genetics)Biologymedicine.diseaseBioinformaticshumanitiesALDH1A203 medical and health sciences030104 developmental biologymedicine.anatomical_structureOncologyGenetic variationCancer researchmedicineAdenocarcinomaRadiology Nuclear Medicine and imagingEsophagusGeneCancer Medicine

researchProduct

Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma

2020

Contains fulltext : 235640.pdf (Publisher’s version ) (Closed access) Genome-wide association studies (GWAS) of esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE), have uncovered significant genetic components of risk, but most heritability remains unexplained. Targeted assessment of genetic variation in biologically relevant pathways using novel analytical approaches may identify missed susceptibility signals. Central obesity, a key BE/EAC risk factor, is linked to systemic inflammation, altered hormonal signaling and insulin-like growth factor (IGF) axis dysfunction. Here, we assessed IGF-related genetic variation and risk of BE and EAC. Principal component analys…

0301 basic medicineOncologyMaleCancer Researchmedicine.medical_specialtyEsophageal NeoplasmsMedizinSingle-nucleotide polymorphismGenome-wide association studyBiologyAdenocarcinomaPolymorphism Single NucleotideReceptor IGF Type 103 medical and health sciencesBarrett Esophagus0302 clinical medicineRisk FactorsSomatomedinsInternal medicineGenetic variationmedicineBiomarkers TumorSNPHumansGenetic Predisposition to DiseaseRisk factorGerm-Line MutationCancer Biomarkers and Molecular EpidemiologyInsulin-like growth factor 1 receptorGenetic associationAgedGeneral MedicineMiddle Agedmedicine.diseaseRenal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11]030104 developmental biology030220 oncology & carcinogenesisBarrett's esophagusFemaleHuman medicineCarrier ProteinsGenome-Wide Association StudySignal TransductionCarcinogenesis

researchProduct

Competitive Profiling of Ligandable Cysteines in Staphylococcus aureus with an Organogold Compound

2022

With the idea of exploiting metal-templated reactions to achieve selective modification of cysteines in proteins for antibacterial applications, an organometallic cyclometalated Au(III) compound was explored in a competitive chemoproteomic approach based on the isoDTB-ABPP (isotopically labelled desthiobiotin azide-activity-based protein profiling) technology in S. aureus cell extracts. In this way, more than 100 ligandable cysteines where identified, of which 10 were close to functional sites of proteins encoded by essential genes indicating potential for antibiotic development. Interestingly, more than 50% of the identified ligandable sites were not engaged by organic α-chloroacetamides i…

Staphylococcus aureusMaterials ChemistryMetals and AlloysCeramics and CompositesCysteineGeneral ChemistryOrganogold CompoundsCatalysisSurfaces Coatings and FilmsElectronic Optical and Magnetic Materials

researchProduct

No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study.

2019

Contains fulltext : 215282.pdf (Publisher’s version ) (Closed access) BACKGROUND & AIMS: Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting results. We conducted a Mendelian randomization study to determine the associations between circulating concentrations of 25(OH)D and risks of EAC and its precursor, Barrett's esophagus (BE). METHODS: We conducted a Mendelian randomization study using a 2-sample (summary data) approach. Six single-nucleotide polymorphisms (SNPs; rs3755967, rs10741657, rs12785878, rs10745742, rs8018720, and rs17216707) associated with circulating concentrations of 25(O…

Malemedicine.medical_specialtyEsophageal NeoplasmsMedizinSingle-nucleotide polymorphismAdenocarcinomaGastroenterologyPolymorphism Single NucleotideRisk AssessmentArticleBarrett EsophagusRisk FactorsInternal medicineMendelian randomizationEpidemiologymedicineVitamin D and neurologyBiomarkers TumorSNPHumansVitamin DHepatologybusiness.industryGastroenterologyOdds ratioDNA NeoplasmEsophageal cancerMendelian Randomization Analysismedicine.diseaseEuropeRenal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11]Barrett's esophagusNorth AmericaFemaleMorbiditybusinessClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

researchProduct

Phase Behavior ofn-Alkyl-substituted Polysilanes

2007

chemistry.chemical_classificationMaterials sciencechemistryPhase (matter)Polymer chemistryOrganic chemistryHigh molecular weight polymerAlkyl

researchProduct

CCDC 2202919: Experimental Crystal Structure Determination

2022

Related Article: Clemens Kaußler, Darren Wragg, Claudia Schmidt, Guillermo Moreno-Alcántar, Christian Jandl, Johannes Stephan, Roland A. Fischer, Stefano Leoni, Angela Casini, Riccardo Bonsignore|2022|Inorg.Chem.|61|20405|doi:10.1021/acs.inorgchem.2c03041

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersbis(mu-11'-methylenebis(3-methyl-23-dihydro-1H-benzimidazol-2-ylidene))-di-gold(i) bis(hexafluorophosphate) acetonitrile diethyl ether solvateExperimental 3D Coordinates

researchProduct

CCDC 2143205: Experimental Crystal Structure Determination

2022

Related Article: Brech Aikman, Riccardo Bonsignore, Ben Woods, Daniel Doellerer, Riccardo Scotti, Claudia Schmidt, Alexandra A. Heidecker, Alexander Pöthig, Edward J. Sayers, Arwyn T. Jones, Angela Casini|2022|Dalton Trans.|51|7476|doi:10.1039/D2DT00337F

Space GroupCrystallographyCrystal SystemCrystal Structuretris(mu-35-bis((pyridin-3-yl)ethynyl)benzoic acid)-(mu-(35-bis((pyridin-3-yl)ethynyl)phenyl)acetate)-di-palladium(ii) tris(tetrafluoroborate) diethyl ether solvateCell ParametersExperimental 3D Coordinates

researchProduct

CCDC 2202918: Experimental Crystal Structure Determination

2022

Space GroupCrystallographyCrystal Systembis(mu-11'-(ethane-12-diyl)bis(3-methyl-23-dihydro-1H-benzimidazol-2-ylidene))-di-gold(i) bis(hexafluorophosphate) acetonitrile solvateCrystal StructureCell ParametersExperimental 3D Coordinates

researchProduct

CCDC 2202916: Experimental Crystal Structure Determination

2022

Space GroupCrystallographyCrystal System11'-(propane-13-diyl)bis(3-methyl-1H-benzimidazol-3-ium) bis[tetrafluoroborate]Crystal StructureCell ParametersExperimental 3D Coordinates

researchProduct

CCDC 2202920: Experimental Crystal Structure Determination

2022

Space GroupCrystallographyCrystal SystemCrystal Structurebis(bis(mu-77'-(propane-13-diyl)bis(139-trimethyl-26-dioxo-236789-hexahydro-1H-purin-8-ylidene))-di-gold(i)) tetrakis(hexafluorophosphate) NN-dimethylformamide diethyl ether solvateCell ParametersExperimental 3D Coordinates

researchProduct

CCDC 2202917: Experimental Crystal Structure Determination

2022

bis(mu-77'-(ethane-12-diyl)bis(139-trimethyl-26-dioxo-236789-hexahydro-1H-purin-8-ylidene))-di-gold(i) bis(hexafluorophosphate) NN-dimethylformamide solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates

researchProduct