0000000001305306

AUTHOR

Roland A. Fischer

showing 6 related works from this author

"Dynamical Docking" of Cyclic Dinuclear Au(I) Bis-N-heterocyclic Complexes Facilitates Their Binding to G-Quadruplexes.

2022

With the aim to improve the design of metal complexes as stabilizers of noncanonical DNA secondary structures, namely, G-quadruplexes (G4s), a series of cyclic dinuclear Au(I) N-heterocyclic carbene complexes based on xanthine and benzimidazole ligands has been synthesized and characterized by various methods, including X-ray diffraction. Fluorescence resonance energy transfer (FRET) and CD DNA melting assays unraveled the compounds’ stabilization properties toward G4s of different topologies of physiological relevance. Initial structure–activity relationships have been identified and recognize the family of xanthine derivatives as those more selective toward G4s versus duplex DNA. The bind…

Inorganic ChemistryG-quadruplexPhysical and Theoretical ChemistryInorganic chemistry
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CCDC 2202919: Experimental Crystal Structure Determination

2022

Related Article: Clemens Kaußler, Darren Wragg, Claudia Schmidt, Guillermo Moreno-Alcántar, Christian Jandl, Johannes Stephan, Roland A. Fischer, Stefano Leoni, Angela Casini, Riccardo Bonsignore|2022|Inorg.Chem.|61|20405|doi:10.1021/acs.inorgchem.2c03041

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersbis(mu-11'-methylenebis(3-methyl-23-dihydro-1H-benzimidazol-2-ylidene))-di-gold(i) bis(hexafluorophosphate) acetonitrile diethyl ether solvateExperimental 3D Coordinates
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CCDC 2202918: Experimental Crystal Structure Determination

2022

Related Article: Clemens Kaußler, Darren Wragg, Claudia Schmidt, Guillermo Moreno-Alcántar, Christian Jandl, Johannes Stephan, Roland A. Fischer, Stefano Leoni, Angela Casini, Riccardo Bonsignore|2022|Inorg.Chem.|61|20405|doi:10.1021/acs.inorgchem.2c03041

Space GroupCrystallographyCrystal Systembis(mu-11'-(ethane-12-diyl)bis(3-methyl-23-dihydro-1H-benzimidazol-2-ylidene))-di-gold(i) bis(hexafluorophosphate) acetonitrile solvateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2202916: Experimental Crystal Structure Determination

2022

Related Article: Clemens Kaußler, Darren Wragg, Claudia Schmidt, Guillermo Moreno-Alcántar, Christian Jandl, Johannes Stephan, Roland A. Fischer, Stefano Leoni, Angela Casini, Riccardo Bonsignore|2022|Inorg.Chem.|61|20405|doi:10.1021/acs.inorgchem.2c03041

Space GroupCrystallographyCrystal System11'-(propane-13-diyl)bis(3-methyl-1H-benzimidazol-3-ium) bis[tetrafluoroborate]Crystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2202920: Experimental Crystal Structure Determination

2022

Related Article: Clemens Kaußler, Darren Wragg, Claudia Schmidt, Guillermo Moreno-Alcántar, Christian Jandl, Johannes Stephan, Roland A. Fischer, Stefano Leoni, Angela Casini, Riccardo Bonsignore|2022|Inorg.Chem.|61|20405|doi:10.1021/acs.inorgchem.2c03041

Space GroupCrystallographyCrystal SystemCrystal Structurebis(bis(mu-77'-(propane-13-diyl)bis(139-trimethyl-26-dioxo-236789-hexahydro-1H-purin-8-ylidene))-di-gold(i)) tetrakis(hexafluorophosphate) NN-dimethylformamide diethyl ether solvateCell ParametersExperimental 3D Coordinates
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CCDC 2202917: Experimental Crystal Structure Determination

2022

Related Article: Clemens Kaußler, Darren Wragg, Claudia Schmidt, Guillermo Moreno-Alcántar, Christian Jandl, Johannes Stephan, Roland A. Fischer, Stefano Leoni, Angela Casini, Riccardo Bonsignore|2022|Inorg.Chem.|61|20405|doi:10.1021/acs.inorgchem.2c03041

bis(mu-77'-(ethane-12-diyl)bis(139-trimethyl-26-dioxo-236789-hexahydro-1H-purin-8-ylidene))-di-gold(i) bis(hexafluorophosphate) NN-dimethylformamide solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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