0000000001305447
AUTHOR
Y. Miyashita
TH-302 + Gemcitabine (G + T) vs Gemcitabine (G) in Patients with Previously Untreated advanced Pancreatic Cancer (PAC)
ABSTRACT Background TH-302 is a hypoxia targeted prodrug with a hypoxia-triggered 2-nitroimidazole component designed to release the DNA alkylator, bromo-isophosphoramide mustard (Br-IPM), when reduced in severe hypoxia. A randomized Phase 2B study (NCT01144455) was conducted to assess the benefit of G + T to standard dose G as first-line therapy of PAC. Materials and methods An open-label multi-center study of two dose levels of TH-302 (240 mg/m2 or 340 mg/m2) in combination with G versus G alone (randomized 1:1:1). G (1000 mg/m2) and T were administered IV over 30-60 minutes on Days 1, 8 and 15 of a 28-day cycle. Patients on the G could crossover after progression and be randomized to a G…
CCDC 714443: Experimental Crystal Structure Determination
Related Article: R.Sen, A.Bhattacharjee, P.Gutlich, Y.Miyashita, K.Okamoto, S.Koner|2009|Inorg.Chim.Acta|362|4663|doi:10.1016/j.ica.2009.06.036
CCDC 748445: Experimental Crystal Structure Determination
Related Article: D.Mal, R.Sen, E.Rentschler, K.Okamoto, Y.Miyashita, S.Koner|2012|Inorg.Chim.Acta|385|27|doi:10.1016/j.ica.2011.12.026
CCDC 748444: Experimental Crystal Structure Determination
Related Article: D.Mal, R.Sen, E.Rentschler, K.Okamoto, Y.Miyashita, S.Koner|2012|Inorg.Chim.Acta|385|27|doi:10.1016/j.ica.2011.12.026
CCDC 714442: Experimental Crystal Structure Determination
Related Article: R.Sen, A.Bhattacharjee, P.Gutlich, Y.Miyashita, K.Okamoto, S.Koner|2009|Inorg.Chim.Acta|362|4663|doi:10.1016/j.ica.2009.06.036
CCDC 714441: Experimental Crystal Structure Determination
Related Article: R.Sen, A.Bhattacharjee, P.Gutlich, Y.Miyashita, K.Okamoto, S.Koner|2009|Inorg.Chim.Acta|362|4663|doi:10.1016/j.ica.2009.06.036
CCDC 645212: Experimental Crystal Structure Determination
Related Article: D.Mal, R.Sen, C.Adhikary, Y.Miyashita, K.-I.Okamoto, A.Bhattacharjee, P.Gutlich, S.Koner|2008|J.Coord.Chem.|61|3486|doi:10.1080/00958970802072773
CCDC 645213: Experimental Crystal Structure Determination
Related Article: D.Mal, R.Sen, C.Adhikary, A.Bhattacharjee, P.Gutlich, Y.Miyashita, K.-I.Okamoto, S.Koner|2008|Inorg.Chim.Acta|361|183|doi:10.1016/j.ica.2007.07.011
CCDC 609951: Experimental Crystal Structure Determination
Related Article: D.Mal, C.Adhikary, E.Rentschler, Y.Miyashita, K.-i.Okamoto, S.Koner|2007|Polyhedron|26|736|doi:10.1016/j.poly.2006.08.037