0000000001305447

AUTHOR

Y. Miyashita

showing 9 related works from this author

TH-302 + Gemcitabine (G + T) vs Gemcitabine (G) in Patients with Previously Untreated advanced Pancreatic Cancer (PAC)

2012

ABSTRACT Background TH-302 is a hypoxia targeted prodrug with a hypoxia-triggered 2-nitroimidazole component designed to release the DNA alkylator, bromo-isophosphoramide mustard (Br-IPM), when reduced in severe hypoxia. A randomized Phase 2B study (NCT01144455) was conducted to assess the benefit of G + T to standard dose G as first-line therapy of PAC. Materials and methods An open-label multi-center study of two dose levels of TH-302 (240 mg/m2 or 340 mg/m2) in combination with G versus G alone (randomized 1:1:1). G (1000 mg/m2) and T were administered IV over 30-60 minutes on Days 1, 8 and 15 of a 28-day cycle. Patients on the G could crossover after progression and be randomized to a G…

medicine.medical_specialtyGastrointestinal tumorsPerformance statusbusiness.industryHematologySevere hypoxiaNeutropeniamedicine.diseaseRashGastroenterologyDiscontinuationNon colorectalOncologyInternal medicineToxicitymedicinemedicine.symptombusinessAnnals of Oncology
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CCDC 714443: Experimental Crystal Structure Determination

2010

Related Article: R.Sen, A.Bhattacharjee, P.Gutlich, Y.Miyashita, K.Okamoto, S.Koner|2009|Inorg.Chim.Acta|362|4663|doi:10.1016/j.ica.2009.06.036

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterscatena-[bis((mu2-Cyanocyanamidato-N1N5)-(1H-imidazol-3-yl))-cobalt(ii)]Experimental 3D Coordinates
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CCDC 748445: Experimental Crystal Structure Determination

2012

Related Article: D.Mal, R.Sen, E.Rentschler, K.Okamoto, Y.Miyashita, S.Koner|2012|Inorg.Chim.Acta|385|27|doi:10.1016/j.ica.2011.12.026

catena-(bis(mu~2~-dicyanamide)-(NN-diethylethane-12-diamine)-nickel(ii))Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 748444: Experimental Crystal Structure Determination

2012

Related Article: D.Mal, R.Sen, E.Rentschler, K.Okamoto, Y.Miyashita, S.Koner|2012|Inorg.Chim.Acta|385|27|doi:10.1016/j.ica.2011.12.026

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterscatena-(bis(mu~2~-dicyanamide)-(NN-diethylethane-12-diamine)-cobalt(ii))Experimental 3D Coordinates
researchProduct

CCDC 714442: Experimental Crystal Structure Determination

2010

Related Article: R.Sen, A.Bhattacharjee, P.Gutlich, Y.Miyashita, K.Okamoto, S.Koner|2009|Inorg.Chim.Acta|362|4663|doi:10.1016/j.ica.2009.06.036

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterscatena-(bis((mu2-Cyanocyanamidato-N1N5)-(1H-imidazol-3-yl))-nickel(ii))Experimental 3D Coordinates
researchProduct

CCDC 714441: Experimental Crystal Structure Determination

2010

Related Article: R.Sen, A.Bhattacharjee, P.Gutlich, Y.Miyashita, K.Okamoto, S.Koner|2009|Inorg.Chim.Acta|362|4663|doi:10.1016/j.ica.2009.06.036

Space GroupCrystallographyCrystal SystemCrystal Structurecatena-(bis((mu~2~-Cyanocyanamidato-N^1^N^3^)-(1H-imidazol-3-yl))-copper)Cell ParametersExperimental 3D Coordinates
researchProduct

CCDC 645212: Experimental Crystal Structure Determination

2009

Related Article: D.Mal, R.Sen, C.Adhikary, Y.Miyashita, K.-I.Okamoto, A.Bhattacharjee, P.Gutlich, S.Koner|2008|J.Coord.Chem.|61|3486|doi:10.1080/00958970802072773

(mu~2~-Dicyanamide)-bis(1-(N-salicylideneimino)-2-(NN-dimethylamino)ethane)-di-copper(ii) perchlorateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 645213: Experimental Crystal Structure Determination

2008

Related Article: D.Mal, R.Sen, C.Adhikary, A.Bhattacharjee, P.Gutlich, Y.Miyashita, K.-I.Okamoto, S.Koner|2008|Inorg.Chim.Acta|361|183|doi:10.1016/j.ica.2007.07.011

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterscatena-((mu~2~-dicyanamide)-aqua-(bis(2-aminoethyl)amido)-nickel(ii) nitrate)Experimental 3D Coordinates
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CCDC 609951: Experimental Crystal Structure Determination

2007

Related Article: D.Mal, C.Adhikary, E.Rentschler, Y.Miyashita, K.-i.Okamoto, S.Koner|2007|Polyhedron|26|736|doi:10.1016/j.poly.2006.08.037

Space GroupCrystallographyCrystal Systemcatena-(bis(mu~2~-Dicyanamido-NN'')-bis(dicyanamido-N)-bis(NN-diethylethane-12-diamine-NN')-di-copper(ii))Crystal StructureCell ParametersExperimental 3D Coordinates
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