Author: Hans-joachim Räder

0000000001307298

AUTHOR

Hans-joachim Räder

showing 3 related works from this author

Site-specific DBCO modification of DEC205 antibody for polymer conjugation

2018

The design of multifunctional polymer-based vectors, forming pDNA vaccines, offers great potential in cancer immune therapy. The transfection of dendritic immune cells (DCs) with tumour antigen-encoding pDNA leads to an activation of the immune system to combat tumour cells. In this work, we investigated the chemical attachment of DEC205 antibodies (aDEC205) as DC-targeting structures to polyplexes of P(Lys)-b-P(HPMA). The conjugation of a synthetic block copolymer and a biomacromolecule with various functionalities (aDEC205) requires bioorthogonal techniques to avoid side reactions. Click chemistry and in particular the strain-promoted alkyne-azide cycloaddition (SPAAC) can provide the req…

540 Chemistry and allied sciencesRAFT polymerizationpDNA polyplexvaccinationbioorthogonal chemistryArticleDEC205 antibodylcsh:QD241-441strain-promoted alkyne-azide cycloaddition (SPAAC)lcsh:Organic chemistry540 Chemiecancer immune therapydendritic cells (DCs)targeting

researchProduct

CCDC 1858028: Experimental Crystal Structure Determination

2018

Related Article: Christian Muhl, Olga Schäfer, Tobias Bauer, Hans-Joachim Räder, Matthias Barz|2018|Macromolecules|51|8188|doi:10.1021/acs.macromol.8b01442

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D CoordinatesS-[2-(25-dioxo-13-oxazolidin-4-yl)ethyl] ethanesulfonothioate

researchProduct

CCDC 1858027: Experimental Crystal Structure Determination

2018

Related Article: Christian Muhl, Olga Schäfer, Tobias Bauer, Hans-Joachim Räder, Matthias Barz|2018|Macromolecules|51|8188|doi:10.1021/acs.macromol.8b01442

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersS-Ethylsulfonyl-L-homocysteineExperimental 3D Coordinates

researchProduct

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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LSLife Sciences
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