0000000001307838
AUTHOR
Carla Queirós
Fluoroquinolone–metal complexes: A route to counteract bacterial resistance?
Abstract Microbial resistance to antibiotics is one of the biggest public health threats of the modern world. Antibiotic resistance is an area of much clinical relevance and therefore research that has the potential to identify agents that may circumvent it or treat resistant infections is paramount. Solution behavior of various fluoroquinolone (FQ) complexes with copper(II) in the presence and absence of 1,10-phenanthroline (phen) was studied in aqueous solution, by potentiometry and/or spectrophotometry, and are herein described. The results obtained showed that under physiological conditions (micromolar concentration range and pH 7.4) only copper(II):FQ:phen ternary complexes are stable.…
The Influence of the Amide Linkage in the FeIII-Binding Properties of Catechol-Modified Rosamine Derivatives
The two new fluorescent ligands RosCat1 and RosCat2 contain catechol receptors connected to rosamine platforms through an amide linkage and were synthesized by using microwave-assisted coupling reactions of carboxyl- or amine-substituted rosamines with the corresponding catechol units and subsequent deprotection. RosCat1 possesses a reverse amide, whereas RosCat2 has the usual oriented amide bond (HNCO vs. CONH, respectively). The ligands were characterized by means of NMR spectroscopy, mass-spectrometry, and DFT calculations and X-ray crystallography studies for RosCat1. The influence of the amide linkage on the photophysical properties of the fluorescent ligands was assessed in different …
Synthesis, characterization, and cellular investigations of porphyrin– and chlorin–indomethacin conjugates for photodynamic therapy of cancer
Indomethacin is a potent non-steroidal anti-inflammatory drug (NSAID) with a strong selective inhibitor activity towards cyclooxygenase-2 (COX-2), an enzyme that is highly overexpressed in various tumour cells, being involved in tumourigenesis. Concomitantly, porphyrins have gained much attention as promising photosensitizers (PSs) for the non-invasive photodynamic therapy (PDT) of cancer. Herein, we report the design, and determine the singlet oxygen generation capacity and in vitro cellular toxicity of porphyrin- and chlorin-indomethacin conjugates (P2-Ind and C2-Ind). Both the conjugates were obtained in high yields and were characterized by 1H, 19F and 13C NMR as well as by high resolut…
CCDC 990231: Experimental Crystal Structure Determination
Related Article: Maria J. Feio, Isabel Sousa, Mariana Ferreira, Luís Cunha-Silva, Raúl G. Saraiva, Carla Queirós, José G. Alexandre, Vasco Claroa, AdéliaMendes, RosaOrtiz, Sandra Lopes, Ana Luísa Amaral, João Lino, Patrícia Fernandes, Ana João Silva, Lisete Moutinho, Baltazar de Castro, Eulália Pereira, Lourdes Perelló, Paula Gameiro|2014|J.Inorg.Biochem.|138|129|doi:10.1016/j.jinorgbio.2014.05.007
CCDC 1402129: Experimental Crystal Structure Determination
Related Article: Carla Queirós, Andreia Leite, Maria G. M. Couto, mLuís Cunha-Silva, Giampaolo Barone, Baltazar de Castro, Maria Rangel, André M. N. Silva, Ana M. G. Silva|2015|Chem.-Eur.J.|21|15692|doi:10.1002/chem.201502093
CCDC 990233: Experimental Crystal Structure Determination
Related Article: Maria J. Feio, Isabel Sousa, Mariana Ferreira, Luís Cunha-Silva, Raúl G. Saraiva, Carla Queirós, José G. Alexandre, Vasco Claroa, AdéliaMendes, RosaOrtiz, Sandra Lopes, Ana Luísa Amaral, João Lino, Patrícia Fernandes, Ana João Silva, Lisete Moutinho, Baltazar de Castro, Eulália Pereira, Lourdes Perelló, Paula Gameiro|2014|J.Inorg.Biochem.|138|129|doi:10.1016/j.jinorgbio.2014.05.007