0000000001308005
AUTHOR
Edward J. Sayers
Highly-fluorescent BODIPY-functionalised metallacages as drug delivery systems
With the aim of designing new metallosupramolecular architectures for drug delivery, research has focused on porous 3-dimensional (3D)-metallacages able to encapsulate cytotoxic agents protecting them from metabolism while targeting them to cancer sites. Here, two self-assembled [Pd2L4]4+ cages (CG1 and CG2) featuring 3,5-bis(3-ethynylpyridine)phenyl ligands (L) exo-functionalised with dipyrromethene (BODIPY) groups have been synthesised and characterised by different methods, including NMR spectroscopy and mass spectrometry. 1H NMR spectroscopy studies shows that the cages are able to encapsulate the anticancer drug cisplatin in their hydrophobic cavity, as evidenced by electrostatic poten…
CCDC 2143205: Experimental Crystal Structure Determination
Related Article: Brech Aikman, Riccardo Bonsignore, Ben Woods, Daniel Doellerer, Riccardo Scotti, Claudia Schmidt, Alexandra A. Heidecker, Alexander Pöthig, Edward J. Sayers, Arwyn T. Jones, Angela Casini|2022|Dalton Trans.|51|7476|doi:10.1039/D2DT00337F