0000000001308010
AUTHOR
Shashi Kant
PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1
AbstractFluid shear stress (FSS) is known to mediate multiple phenotypic changes in the endothelium. Laminar FSS (undisturbed flow) is known to promote endothelial alignment to flow that is key to stabilizing the endothelium and rendering it resistant to atherosclerosis and thrombosis. The molecular pathways responsible for endothelial responses to FSS are only partially understood. Here we have identified peroxisome proliferator gamma coactivator-1α (PGC-1α) as a flow-responsive gene required for endothelial flow alignment in vitro and in vivo. Compared to oscillatory FSS (disturbed flow) or static conditions, laminar FSS (undisturbed flow) increased PGC-1α expression and its transcription…
Dimeric Mn(ii), Co(ii), Ni(ii) and Cu(ii) complexes of a common carboxylate-appended (2-pyridyl)alkylamine ligand: structure, magnetism and DFT study
Four new complexes of composition [MII2(L3)2(CH3OH)2](ClO4)2 (M = Mn, 1; Co, 2; Ni, 3) and [CuII2(L3)2](ClO4)2 (4) (L3(−) = 3-[2-(((6-methyl)pyridin-2-yl)methyl){(dimethylamino)ethyl}-amino]propionate) have been synthesized and characterized. Structural analysis reveals that 1–4 are discrete syn–anti carboxylate-bridged binuclear coordination complexes with a {MII2(–O–C–O–)2}2+ structural motif. In 1–3 distorted octahedral MN3O3 and in 4 distorted square pyramidal CuN3O2 coordination is satisfied at each M(II) center by three N (a pyridyl and two tertiary aliphatic amines) and a carboxylate O of the ligand, and an O of the carboxylate group. In 1–3 the M(II) center is also coordinated by a …
CCDC 1965761: Experimental Crystal Structure Determination
Related Article: Munirathnam Manda, Himanshu Arora, Arunava Sengupta, Shashi Kant, Francesc Lloret, Rabindranath Mukherjee|2021|New J.Chem.|45|16019|doi:10.1039/D1NJ01150B
CCDC 1965763: Experimental Crystal Structure Determination
Related Article: Munirathnam Manda, Himanshu Arora, Arunava Sengupta, Shashi Kant, Francesc Lloret, Rabindranath Mukherjee|2021|New J.Chem.|45|16019|doi:10.1039/D1NJ01150B
CCDC 1965760: Experimental Crystal Structure Determination
Related Article: Munirathnam Manda, Himanshu Arora, Arunava Sengupta, Shashi Kant, Francesc Lloret, Rabindranath Mukherjee|2021|New J.Chem.|45|16019|doi:10.1039/D1NJ01150B
CCDC 1965762: Experimental Crystal Structure Determination
Related Article: Munirathnam Manda, Himanshu Arora, Arunava Sengupta, Shashi Kant, Francesc Lloret, Rabindranath Mukherjee|2021|New J.Chem.|45|16019|doi:10.1039/D1NJ01150B