0000000001308018

AUTHOR

Walhan Alshaer

showing 2 related works from this author

Acetic Acid Mediated for One-Pot Synthesis of Novel Pyrazolyl s-Triazine Derivatives for the Targeted Therapy of Triple-Negative Breast Tumor Cells (…

2022

Here, we described the synthesis of novel pyrazole-s-triazine derivatives via an easy one-pot procedure for the reaction of β-dicarbonyl compounds (ethylacetoacetate, 5,5-dimethyl-1,3-cyclohexadione or 1,3-cyclohexadionone) with N,N-dimethylformamide dimethylacetal, followed by addition of 2-hydrazinyl-4,6-disubstituted-s-triazine either in ethanol-acetic acid or neat acetic acid to afford a novel pyrazole and pyrazole-fused cycloalkanone systems. The synthetic protocol proved to be efficient, with a shorter reaction time and high chemical yield with broad substrates. The new pyrazolyl-s-triazine derivatives were tested against the following cell lines: MCF-7 (breast cancer); MDA-MB-231 (tr…

kemiallinen synteesiDMF-DMAlääkekemiabioaktiiviset yhdisteetAnticancer profilePharmaceutical ScienceApoptosisOne-pot synthesisheterosykliset yhdisteetPyrazolyl-s-triazineone-pot synthesis; DMF-DMA; pyrazolyl-<i>s</i>-triazine; anticancer profile; EGFR/PI3K/AKT/mTOR; apoptosisinhibiittoritEGFR/PI3K/AKT/mTOR
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CCDC 2177427: Experimental Crystal Structure Determination

2022

Related Article: Ihab Shawish, Assem Barakat, Ali Aldalbahi, Walhan Alshaer, Fadwa Daoud, Dana A. Alqudah, Mazhar Al Zoubi, Ma’mon M. Hatmal, Mohamed S. Nafie, Matti Haukka, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio, Ayman El-Faham|2022|Pharmaceutics|14|1558|doi:10.3390/pharmaceutics14081558

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters1-[4-(4-methoxyanilino)-6-(piperidin-1-yl)-135-triazin-2-yl]-1567-tetrahydro-4H-indazol-4-one dimethyl sulfoxide solvateExperimental 3D Coordinates
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