0000000001308124
AUTHOR
Hanna Jędrzejewska
Dynamic formation of hybrid peptidic capsules by chiral self-sorting and self-assembly.
Owing to their versatility and biocompatibility, peptide-based self-assembled structures constitute valuable targets for complex functional designs. It is now shown that artificial capsules based on β-barrel binding motifs can be obtained by means of dynamic covalent chemistry (DCC) and self-assembly. Short peptides (up to tetrapeptides) are reversibly attached to resorcinarene scaffolds. Peptidic capsules are thus selectively formed in either a heterochiral or a homochiral way by simultaneous and spontaneous processes, involving chiral sorting, tautomerization, diastereoselective induction of inherent chirality, and chiral self-assembly. Self-assembly is shown to direct the regioselectivit…
CCDC 1006725: Experimental Crystal Structure Determination
Related Article: Hanna Jędrzejewska, Michał Wierzbicki, Piotr Cmoch, Kari Rissanen, Agnieszka Szumna|2014|Angew.Chem.,Int.Ed.|53|13760|doi:10.1002/anie.201407802
CCDC 1006724: Experimental Crystal Structure Determination
Related Article: Hanna Jędrzejewska, Michał Wierzbicki, Piotr Cmoch, Kari Rissanen, Agnieszka Szumna|2014|Angew.Chem.,Int.Ed.|53|13760|doi:10.1002/anie.201407802
CCDC 1006726: Experimental Crystal Structure Determination
Related Article: Hanna Jędrzejewska, Michał Wierzbicki, Piotr Cmoch, Kari Rissanen, Agnieszka Szumna|2014|Angew.Chem.,Int.Ed.|53|13760|doi:10.1002/anie.201407802