0000000001308433
AUTHOR
Georg Manolikakes
showing 5 related works from this author
Advances in photochemical and electrochemical incorporation of sulfur dioxide for the synthesis of value-added compounds.
2021
Organic photochemistry and electrochemistry currently receive tremendous attention in organic synthesis as both techniques enable the reagent-less activation of organic molecules without using expensive and hazardous redox reagents. The incorporation of SO2 into organic molecules is a relatively modern research topic, which likewise gains immense popularity since the discovery of the SO2 surrogate DABSO. Sulfur-containing organic molecules are omnipresent in pharmaceuticals and agrochemicals. This review covers the recent progress in electrochemical and photochemical methodologies for the incorporation and uses of SO2 in the synthesis of value-added compounds. Additionally, different work t…
Cytoprotective and antioxidant properties of organic selenides for the myelin-forming cells, oligodendrocytes.
2018
Abstract Here a new series of twenty-one organoselenides, of potential protective activity, were synthesized and tested for their intrinsic cytotoxicity, anti-apoptotic and antioxidant capacities in oligodendrocytes. Most of the organoselenides were able to decrease the ROS levels, revealing antioxidant properties. Compounds 5b and 7b showed a high glutathione peroxidase (GPx)-like activities, which were 1.5 folds more active than ebselen. Remarkably, compound 5a diminished the formation of the oligodendrocytes SubG1 peak in a concentration-dependent manner, indicating its anti-apoptotic properties. Furthermore, based on the SwissADME web interface, we performed an in-silico structure-activ…
Electron diffraction tomography and X-ray powder diffraction on photoredox catalyst PDI
2019
N,N-Bis(2,6-diisopropylphenyl)-perylene-3,4,9,10-bis(dicarboximide) (PDI-iPr) is starting to be widely used as a metal-free homogeneous photoredox catalyst. The crystal structure was determined by a combination of electron diffraction tomography and X-ray powder diffraction and further validated by DFT-D calculations. Surprisingly, the molecular geometry of PDI-iPr leads to voids in the packing.
CCDC 1857633: Experimental Crystal Structure Determination
2019
Related Article: Alexander Bodach, Haishuang Zhao, Nai Liu, Edith Alig, Georg Manolikakes, Ute Kolb, Lothar Fink|2019|CrystEngComm|21|2571|doi:10.1039/C8CE02026D
CCDC 1472956: Experimental Crystal Structure Determination
2020
Related Article: Saad Shaaban, Dominique Vervandier-Fasseur, Pierre Andreoletti, Amira Zarrouk, Philippe Richard, Amr Negm, Georg Manolikakes, Claus Jacob, Mustapha Cherkaoui-Malki|2018|Bioorg.Chem.|80|43|doi:10.1016/j.bioorg.2018.05.019