GLP-2 receptor expression in excitatory and inhibitory enteric neurons and its role in mouse duodenum contractility.

Background. Glucagon-like peptide 2 (GLP-2), a nutrient-responsive hormone, exerts various actions in the gastrointestinal tract that are mediated by a G-protein coupled receptor called GLP-2R. A little information is available on GLP-2R expression in enteric neurons and nothing on the interstitial cells of Cajal (ICC). Methods. We investigated presence and distribution of the GLP-2R in the mouse duodenum by immunohistochemistry and the potential motor effects of GLP-2 on the spontaneous and neurally evoked mechanical activity. Key Results. The GLP-2R was expressed by the myenteric and submucosal neurons. Labelling was also present in nerve varicosities within the circular muscular layer an…

Glucagon-like Peptide-2 and mucosal changes induced by high fat diet in mouse small intestine.

CCDC 735809: Experimental Crystal Structure Determination

Related Article: G.Ruisi, L.Canfora, G.Bruno, A.Rotondo, T.F.Mastropietro, E.A.Debbia, M.A.Girasolo, B.Megna|2010|J.Organomet.Chem.|695|546|doi:10.1016/j.jorganchem.2009.11.019

CCDC 633704: Experimental Crystal Structure Determination

Related Article: R.Gitto, R.Ficarra, R.Stancanelli, M.Guardo, L.De Luca, M.L.Barreca, B.Pagano, A.Rotondo, G.Bruno, E.Russo, G.De Sarro, A.Chimirri|2007|Bioorg.Med.Chem.|15|5417|doi:10.1016/j.bmc.2007.05.059

CCDC 735808: Experimental Crystal Structure Determination

Related Article: G.Ruisi, L.Canfora, G.Bruno, A.Rotondo, T.F.Mastropietro, E.A.Debbia, M.A.Girasolo, B.Megna|2010|J.Organomet.Chem.|695|546|doi:10.1016/j.jorganchem.2009.11.019