0000000001308598

AUTHOR

Said El-kurdi

showing 9 related works from this author

Efficient Synthesis and X-ray Structure of [1,2,4]Triazolo[4,3-a]pyridines via Oxidative Cyclization Using N-Chlorosuccinimide (NCS)

2021

Triazolopyridines are a family of compounds that, owing to their biological activity, have many pharmaceutical applications. In this study, 3-(pyridine-4-yl)-[1,2,4]triazolo[4,3-a]pyridine and 6-bromo-3-(pyridine-4-yl)-[1,2,4]triazolo[4,3-a]pyridine were synthesized by using the chlorinated agent NCS for hydrazones under very mild conditions. The characterization of these compounds was achieved by 1H NMR, 13C NMR, FTIR, MS and X-ray diffraction. The compound 3-(pyridine-4-yl)-[1,2,4]triazolo[4,3-a]pyridine was crystallized in the monoclinic space group P 21/c with a = 15.1413(12), b = 6.9179(4), c = 13.0938(8) Å, β = 105.102(6)°, V = 1324.16(16)Å3, Z = 4, and R = 0.0337. Also compound 6-bro…

N-ChlorosuccinimideH-bondingcrystal structureCrystallographysynthesisHydrogen bondGeneral Chemical EngineeringCrystal structureCarbon-13 NMRCondensed Matter PhysicsMedicinal chemistryInorganic Chemistrychemistry.chemical_compoundNCSchemistryQD901-999PyridineProton NMRGeneral Materials ScienceFourier transform infrared spectroscopy124-triazolo[43-<i>a</i>]pyridineMonoclinic crystal systemCrystals
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Design, Synthesis and Biological Evaluation of Novel Pyrazolo[1,2,4]triazolopyrimidine Derivatives as Potential Anticancer Agents

2021

Three novel pyrazolo-[4,3-e][1,2,4]triazolopyrimidine derivatives (1, 2, and 3) were designed, synthesized, and evaluated for their in vitro biological activity. All three compounds exhibited different levels of cytotoxicity against cervical and breast cancer cell lines. However, compound 1 showed the best antiproliferative activity against all tested tumor cell lines, including HCC1937 and HeLa cells, which express high levels of wild-type epidermal growth factor receptor (EGFR). Western blot analyses demonstrated that compound 1 inhibited the activation of EGFR, protein kinase B (Akt), and extracellular signal-regulated kinase (Erk)1/2 in breast and cervical cancer cells at concentrations…

cervical cancercrystal X-ray analysisPharmaceutical ScienceAntineoplastic AgentsArticleAnalytical ChemistryHeLa03 medical and health sciencesbreast cancerQD241-4410302 clinical medicineDrug DiscoveryHumansEpidermal growth factor receptorPhysical and Theoretical Chemistrypyrazolo[124]triazolopyrimidineCytotoxicityProtein Kinase InhibitorsProtein kinase BCell Proliferation030304 developmental biologyMitogen-Activated Protein Kinase 1pyrazolo[124]triazolopyrimidine; EGF-receptor inhibitor; breast cancer; cervical cancer; molecular docking; crystal X-ray analysis0303 health sciencesBinding SitesMitogen-Activated Protein Kinase 3biologyChemistryKinaseOrganic ChemistryBiological activitymolecular dockingTriazolesbiology.organism_classificationMolecular biologyIn vitroErbB ReceptorsMolecular Docking SimulationPyrimidinesChemistry (miscellaneous)Docking (molecular)030220 oncology & carcinogenesisbiology.proteinMolecular MedicineProto-Oncogene Proteins c-aktEGF-receptor inhibitorHeLa CellsProtein BindingMolecules
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CSD 2099609: Experimental Crystal Structure Determination

2021

Related Article: Said El-Kurdi, Bassam Abu Thaher, Kanan Wahedy, Dieter Schollmeyer, Levin Nopper, Oliver Riester, Hans-Peter Deigner|2021|Crystals|11|1156|doi:10.3390/cryst11101156

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CSD 2099612: Experimental Crystal Structure Determination

2021

Related Article: Said El-Kurdi, Bassam Abu Thaher, Kanan Wahedy, Dieter Schollmeyer, Levin Nopper, Oliver Riester, Hans-Peter Deigner|2021|Crystals|11|1156|doi:10.3390/cryst11101156

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CSD 2099610: Experimental Crystal Structure Determination

2021

Related Article: Said El-Kurdi, Bassam Abu Thaher, Kanan Wahedy, Dieter Schollmeyer, Levin Nopper, Oliver Riester, Hans-Peter Deigner|2021|Crystals|11|1156|doi:10.3390/cryst11101156

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2049251: Experimental Crystal Structure Determination

2021

Related Article: Said El-Kurdi, Bassam Abu Thaher, Kanan Wahedy, Dieter Schollmeyer, Levin Nopper, Oliver Riester, Hans-Peter Deigner|2021|Crystals|11|1156|doi:10.3390/cryst11101156

Space GroupCrystallography3-(pyridin-4-yl)[124]triazolo[43-a]pyridine trihydrateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2042388: Experimental Crystal Structure Determination

2021

Related Article: Saeb Aliwaini, Bassam Abu Thaher, Ihab Al-Masri, Nabil Shurrab, Said El-Kurdi, Dieter Schollmeyer, Basem Qeshta, Mariam Ghunaim, Ren�� Csuk, Stefan Laufer, Lars Kaiser, Hans-Peter Deigner|2021|Molecules|26|4065|doi:10.3390/molecules26134065

Space GroupCrystallographyCrystal System4-[7-(4-bromophenyl)-7H-pyrazolo[43-e][124]triazolo[15-c]pyrimidin-9-yl]pyridin-1-ium trifluoroacetate trifluoroacetic acid unknown solvateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2049252: Experimental Crystal Structure Determination

2021

Related Article: Said El-Kurdi, Bassam Abu Thaher, Kanan Wahedy, Dieter Schollmeyer, Levin Nopper, Oliver Riester, Hans-Peter Deigner|2021|Crystals|11|1156|doi:10.3390/cryst11101156

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters6-bromo-3-(pyridin-4-yl)[124]triazolo[43-a]pyridine trihydrateExperimental 3D Coordinates
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CSD 2099611: Experimental Crystal Structure Determination

2021

Related Article: Said El-Kurdi, Bassam Abu Thaher, Kanan Wahedy, Dieter Schollmeyer, Levin Nopper, Oliver Riester, Hans-Peter Deigner|2021|Crystals|11|1156|doi:10.3390/cryst11101156

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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