Author: Robert Sibilski

0000000001309143

AUTHOR

Robert Sibilski

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The impact of oophorectomy on survival from breast cancer in patients with CHEK2 mutations

2022

BACKGROUND: To estimate the impact of oophorectomy and other treatments on the survival of breast cancer patients with a CHEK2 mutation. METHODS: Women with Stage I–III breast cancer who were treated at 17 hospitals in Poland were tested for four founder mutations in the CHEK2 gene. 974 women (10%) were positive for a CHEK2 mutation. Control patients without a CHEK2 mutation were selected from a database of patients treated over the same time period. Information on treatments received and distant recurrences were retrieved from medical records. Treatments included chemotherapy, hormonal therapy (tamoxifen) and radiation therapy. Oophorectomies were performed for the treatment of breast canc…

Cancer ResearchCheckpoint Kinase 2OncologyRisk FactorsOvariectomyMutationHumansBreast NeoplasmsFemaleGenetic Predisposition to DiseaseArticleProportional Hazards Models

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Additional file 1 of Genetic predisposition to male breast cancer in Poland

2021

Additional file 1.

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PEPhysical Sciences and Engineering
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LSLife Sciences
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