0000000001309722
AUTHOR
Ruma Hoque
Synthesis of l -[4-11 C]Asparagine by Ring-Opening Nucleophilic 11 C-Cyanation Reaction of a Chiral Cyclic Sulfamidate Precursor
The development of a convenient and rapid method to synthesize radiolabeled, enantiomerically pure amino acids (AAs) as potential positron emission tomography (PET) imaging agents for mapping various biochemical transformations in living organisms remains a challenge. This is especially true for the synthesis of carbon-11-labeled AAs given the short half-life of carbon-11 (11 C, t1/2 =20.4 min). A facile synthetic pathway to prepare enantiomerically pure 11 C-labeled l-asparagine was developed using a partially protected serine as a starting material with a four-step transformation providing a chiral five-membered cyclic sulfamidate as the radiolabeling precursor. Its structure and absolute…
CCDC 1415388: Experimental Crystal Structure Determination
Related Article: Youwen Xu, Aylin Sibel Cankaya, Ruma Hoque, So Jeong Lee, Colleen Shea, Lena Kersting, Michael Schueller, Joanna S. Fowler, David Szalda, David Alexoff, Barbara Riehl, Tassilo Gleede, Richard A. Ferrieri, Wenchao Qu|2018|Chem.-Eur.J.|24|6848|doi:10.1002/chem.201801029