0000000001309725

AUTHOR

Lena Kersting

showing 3 related works from this author

Dynamic Precision Phenotyping Reveals Mechanism of Crop Tolerance to Root Herbivory.

2016

The western corn rootworm (WCR; Diabrotica virgifera virgifera LeConte) is a major pest of maize (Zea mays) that is well adapted to most crop management strategies. Breeding for tolerance is a promising alternative to combat WCR but is currently constrained by a lack of physiological understanding and phenotyping tools. We developed dynamic precision phenotyping approaches using 11C with positron emission tomography, root autoradiography, and radiometabolite flux analysis to understand maize tolerance to WCR. Our results reveal that WCR attack induces specific patterns of lateral root growth that are associated with a shift in auxin biosynthesis from indole-3-pyruvic acid to indole-3-aceton…

0106 biological sciences0301 basic medicineCrops AgriculturalIndolesPhysiologyGlutamineResearch Articles - Focus IssuePlant Science580 Plants (Botany)01 natural sciencesPlant RootsZea maysHost-Parasite InteractionsCrop03 medical and health sciencesBotanyGeneticsAnimalsCarbon RadioisotopesHerbivoryAmino AcidsPlant DiseasesHerbivorebiologyIndoleacetic AcidsMechanism (biology)Lateral rootfungifood and beveragesBiological Transportbiology.organism_classificationZea maysColeoptera030104 developmental biologyWestern corn rootwormPhenotypeAgronomyPositron-Emission TomographyPEST analysisFlux (metabolism)010606 plant biology & botanyPlant physiology
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Synthesis of l -[4-11 C]Asparagine by Ring-Opening Nucleophilic 11 C-Cyanation Reaction of a Chiral Cyclic Sulfamidate Precursor

2018

The development of a convenient and rapid method to synthesize radiolabeled, enantiomerically pure amino acids (AAs) as potential positron emission tomography (PET) imaging agents for mapping various biochemical transformations in living organisms remains a challenge. This is especially true for the synthesis of carbon-11-labeled AAs given the short half-life of carbon-11 (11 C, t1/2 =20.4 min). A facile synthetic pathway to prepare enantiomerically pure 11 C-labeled l-asparagine was developed using a partially protected serine as a starting material with a four-step transformation providing a chiral five-membered cyclic sulfamidate as the radiolabeling precursor. Its structure and absolute…

chemistry.chemical_classification010405 organic chemistryOrganic ChemistryAbsolute configurationStereoisomerismGeneral ChemistryCyanation010402 general chemistry01 natural sciencesCombinatorial chemistryCatalysis0104 chemical sciencesAmino acidHydrolysisNucleophilechemistryYield (chemistry)AsparagineChemistry - A European Journal
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CCDC 1415388: Experimental Crystal Structure Determination

2018

Related Article: Youwen Xu, Aylin Sibel Cankaya, Ruma Hoque, So Jeong Lee, Colleen Shea, Lena Kersting, Michael Schueller, Joanna S. Fowler, David Szalda, David Alexoff, Barbara Riehl, Tassilo Gleede, Richard A. Ferrieri, Wenchao Qu|2018|Chem.-Eur.J.|24|6848|doi:10.1002/chem.201801029

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersdi-t-butyl 123-oxathiazolidine-34-dicarboxylate 22-dioxideExperimental 3D Coordinates
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