0000000001310403
AUTHOR
Josefa Badia
showing 6 related works from this author
Luminescent Pt-II and Pt-IV Platinacycles with Anticancer Activity Against Multiplatinum-Resistant Metastatic CRC and CRPC Cell Models
2020
Platinum-based chemotherapy persists to be the only effective therapeutic option against a wide variety of tumours. Nevertheless, the acquisition of platinum resistance is utterly common, ultimately cornering conventional platinum drugs to only palliative in many patients. Thus, encountering alternatives that are both effective and non-cross-resistant is urgent. In this work, we report the synthesis, reduction studies, and luminescent properties of a series of cyclometallated (C,N,N')PtIV compounds derived from amine- imine ligands, and their remarkable efficacy at the high nanomolar range and complete lack of cross57 resistance, as an intrinsic property of the platinacycle, against multipl…
Luminescent PtII and PtIV Platinacycles with Anticancer Activity Against Multiplatinum‐Resistant Metastatic CRC and CRPC Cell Models
2020
Abstract: Platinum‐based chemotherapy persists to be the only effective therapeutic option against a wide variety of tumours. Nevertheless, the acquisition of platinum resistance is utterly common, ultimately cornering conventional platinum drugs to only palliative in many patients. Thus, encountering alternatives that are both effective and non‐cross‐resistant is urgent. In this work, we report the synthesis, reduction studies and luminescent properties of a series of cyclometallated (C,N,N’) PtIV compounds derived from amine‐imine ligands, and their remarkable efficacy at the high nanomolar range and complete lack of cross‐resistance, as an intrinsic property of the platinacycle, against …
CCDC 1957891: Experimental Crystal Structure Determination
2020
Related Article: Ariadna Lázaro, Cristina Balcells, Josefina Quirante, Josefa Badia, Laura Baldomà, Jas S. Ward, Kari Rissanen, Mercè Font‐Bardia, Laura Rodríguez, Margarita Crespo, Marta Cascante|2020|Chem.-Eur.J.|26|1947|doi:10.1002/chem.201905325
CCDC 1958053: Experimental Crystal Structure Determination
2020
Related Article: Ariadna Lázaro, Cristina Balcells, Josefina Quirante, Josefa Badia, Laura Baldomà, Jas S. Ward, Kari Rissanen, Mercè Font‐Bardia, Laura Rodríguez, Margarita Crespo, Marta Cascante|2020|Chem.-Eur.J.|26|1947|doi:10.1002/chem.201905325
CCDC 1958051: Experimental Crystal Structure Determination
2020
Related Article: Ariadna Lázaro, Cristina Balcells, Josefina Quirante, Josefa Badia, Laura Baldomà, Jas S. Ward, Kari Rissanen, Mercè Font‐Bardia, Laura Rodríguez, Margarita Crespo, Marta Cascante|2020|Chem.-Eur.J.|26|1947|doi:10.1002/chem.201905325
CCDC 1958052: Experimental Crystal Structure Determination
2020
Related Article: Ariadna Lázaro, Cristina Balcells, Josefina Quirante, Josefa Badia, Laura Baldomà, Jas S. Ward, Kari Rissanen, Mercè Font‐Bardia, Laura Rodríguez, Margarita Crespo, Marta Cascante|2020|Chem.-Eur.J.|26|1947|doi:10.1002/chem.201905325