0000000001310659

AUTHOR

Daniel Vogt

showing 10 related works from this author

Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

2019

Este es el artículo que se ha publicado de forma definitiva en: https://molecularautism.biomedcentral.com/articles/10.1186/s13229-019-0262-8 En este artículo también participa Joan Climent, Vera Pancaldi, Lourdes Fañanás, Celso Arango, Mara Parellada, Anaïs Baudot, Daniel Vogt, John L. Rubenstein, Alfonso Valencia y Rafael Tabarés-Seisdedos. Background: Epidemiological and clinical evidence points to cancer as a comorbidity in people with autism spectrum disorders (ASD). A significant overlap of genes and biological processes between both diseases has also been reported. Methods: Here, for the first time, we compared the gene expression profiles of ASD frontal cortex tissues and 22 cancer t…

Autism.AutismComorbidityBioinformaticsAutismo.lcsh:RC346-429Expresión génica.TranscriptomeAfectividad - Trastornos.0302 clinical medicineNeoplasmsGene expression2.1 Biological and endogenous factorsAetiologyCàncerCáncer - Aspectos genéticos.ComputingMilieux_MISCELLANEOUSCancer0303 health sciencesProstate CancerBrainAffective disorders.3. Good healthPsychiatry and Mental healthMental HealthSignal transductionSignal TransductionBiotechnologyUrologic DiseasesIntellectual and Developmental Disabilities (IDD)1.1 Normal biological development and functioningClinical SciencesBiologyASDBiological pathway03 medical and health sciencesDevelopmental NeuroscienceUnderpinning researchmental disordersGeneticsmedicineHumansAutistic DisorderIntellectual and Developmental DisabilitiesGeneMolecular Biologylcsh:Neurology. Diseases of the nervous systemPI3K/AKT/mTOR pathwayCancer - Genetic aspects.030304 developmental biologyResearchNeurosciencesMultimorbidityCancermedicine.diseaseExpressió gènicaHuman geneticsBrain DisordersMeta-analysisGene expression.AutismGene expressionAutisme[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]TranscriptomeKidney cancer030217 neurology & neurosurgeryDevelopmental BiologyMolecular Autism
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Additional file 1: of Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

2019

Table S1. Datasets included in our study. Table S2. Age, gender and pmi distributions between cases and control samples at each step of the preprocessing procedure at the asd defferentail gene expression meta-analysis. Table S3. Final samples included in the asd meta-analysis. Table S4. Jointly same direction derregulated genes in asd ans sddcs and jointly oposite direction derregulated genes in asd and oddcs. Table S5. Genes jointly deregulated in asd and in sddcs and oddcs. Figure S1. Comaprison of differential gene expression analysis using limma with rlog transformed data and two state of the art rnaseq differential expression metdos. Figure S2. Patient overlap in the three asd studies.…

mental disorders
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Additional file 5: of Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

2019

Full differential gene expression meta-analysis results of cancer data. (ZIP 31237 kb)

population characteristicshuman activities
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Additional file 3: of Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

2019

Full ASD GSEA pre-ranked enrichment results for different molecular signatures (C2, H, GO_BP, GO_CC, and GO_MF). (XLSX 698 kb)

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Additional file 5: of Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

2019

Full differential gene expression meta-analysis results of cancer data. (ZIP 31237 kb)

population characteristicshuman activities
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Additional file 3: of Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

2019

Full ASD GSEA pre-ranked enrichment results for different molecular signatures (C2, H, GO_BP, GO_CC, and GO_MF). (XLSX 698 kb)

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Additional file 4: of Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

2019

gProfileR biological process overrepresentation results of the genes contained in the significant intersections of ASD, SDDCs, and ODDCs. (XLSX 233 kb)

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Additional file 2: of Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

2019

Full ASD differential gene expression meta-analysis results. (CSV 1387 kb)

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Additional file 2: of Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

2019

Full ASD differential gene expression meta-analysis results. (CSV 1387 kb)

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Additional file 4: of Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

2019

gProfileR biological process overrepresentation results of the genes contained in the significant intersections of ASD, SDDCs, and ODDCs. (XLSX 233 kb)

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